Exploring the sequence features determining amyloidosis in human antibody light chains
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DOI: 10.1038/s41598-021-93019-9
Abstract: The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies into amyloid fibrils. There are plenty of computational resources available for the prediction of short aggregation-prone regions within proteins. However,… read more here.
Keywords: aggregation; antibody light; antibody; light ... See more keywords
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
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DOI: 10.3390/antib11020037
Abstract: When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells. When μ chains were paired with κ… read more here.
Keywords: chains key; light chains; expi293 cells; increased monoclonal ... See more keywords