Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer
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DOI: 10.1371/journal.ppat.1010945
Abstract: Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmental… read more here.
Keywords: neutralization breadth; hiv; infected elite; antibody lineages ... See more keywords
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.2210/pdb6osy/pdb
Abstract: The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab… read more here.
Keywords: hiv; neutralization; lineages vaccine; vaccine induced ... See more keywords