Structure‐based computational design of antibody mimetics: challenges and perspectives
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DOI: 10.1002/2211-5463.13855
Abstract: The design of antibody mimetics holds great promise for revolutionizing therapeutic interventions by offering alternatives to conventional antibody therapies. Structure‐based computational approaches have emerged as indispensable tools in the rational design of those molecules, enabling… read more here.
Keywords: structure based; design antibody; antibody mimetics; based computational ... See more keywords
Using different proteolytic enzymes to digest antibody and its impact on stability of antibody mimetics.
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DOI: 10.1016/j.jim.2020.112933
Abstract: There are opportunities to formulate antibodies as solid-state depots for local therapy, which would minimise large systemic doses that are typically required. We have developed antibody mimetics known as Fab-PEG-Fab (FpF) that display similar binding… read more here.
Keywords: fpf; igg; using different; antibody ... See more keywords
Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use
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DOI: 10.1038/s41598-020-57713-4
Abstract: Monoclonal antibodies (mAbs) are attractive therapeutics for treating a wide range of human disorders, and bind to the antigen through their complementarity-determining regions (CDRs). Small stable proteins containing structurally retained CDRs are promising alternatives to… read more here.
Keywords: strategy; antibody mimetics; complementarity determining; create ... See more keywords
Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
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DOI: 10.1038/s42003-021-02487-2
Abstract: Protein-based targeting reagents, such as antibodies and non-antibody scaffold proteins, are rapidly inactivated in the upper gastrointestinal (GI) tract. Hydrochloric acid in gastric juice denatures proteins and activates pepsin, concentrations of which reach 1 mg/mL in… read more here.
Keywords: pepsin; antibody; hydrochloric acid; antibody mimetics ... See more keywords