Chemical Biology Approaches toward Precise Structure Control of IgG‐Based Antibody‐Oligonucleotide Conjugates
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DOI: 10.1002/cbic.202300077
Abstract: Antibody‐oligonucleotide conjugates (AOCs) are important tools for drug development and biochemical analysis. However, the structural heterogeneity of AOCs synthesized through conventional coupling methods raises reproducibility and safety concerns in clinical trials. To address these issues,… read more here.
Keywords: chemical biology; control; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords
Non-specific interactions of antibody-oligonucleotide conjugates with living cells
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DOI: 10.1038/s41598-021-85352-w
Abstract: Antibody-Oligonucleotide Conjugates (AOCs) represent an emerging class of functionalized antibodies that have already been used in a wide variety of applications. While the impact of dye and drug conjugation on antibodies’ ability to bind their… read more here.
Keywords: oligonucleotide conjugates; non specific; living cells; specific interactions ... See more keywords
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
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DOI: 10.1093/nar/gkad415
Abstract: Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody-oligonucleotide conjugates (AOCs) towards mice or monkeys utilizing anti-TfR1… read more here.
Keywords: muscle; conjugates aocs; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords
Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles
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DOI: 10.3390/pharmaceutics15061643
Abstract: Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful of cytotoxic small-molecule payloads. Adaptation of this successful format to the delivery of alternative types of cytotoxic payloads is… read more here.
Keywords: cationic nanoparticles; targeted anticancer; antibody oligonucleotide; oligonucleotide conjugates ... See more keywords