Development of Monoclonal Antibodies: The Dawn of mAb Rule
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4478-1
Abstract: Underlying most major therapeutic advances are fundamental discoveries that shake scientific discourse to its core, usually generating Nobel prizes and entirely new fields of study. In this eighth installment of the series entitled ‘‘Paradigm Shifts… read more here.
Keywords: monoclonal antibodies; antibody production; antibody; plasma cell ... See more keywords
Interleukin-10 (IL-10) participates in host defense against bacterial pathogens and promotes IgM antibody production in Nile tilapia (Oreochromis niloticus)
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.735829
Abstract: Abstract Interleukin 10 (IL-10) is a pleiotropic cytokine with important immune regulation function, not only participating in the differentiation of B cells, but also boosting B cell antibody production in mammals. In this study, OnIL-10… read more here.
Keywords: antibody production; igm antibody; tilapia oreochromis; antibody ... See more keywords
Effects of AS2541019, a novel selective PI3K&dgr; inhibitor, on antibody production and hamster to rat xenotransplantation
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.046
Abstract: &NA; B cell‐mediated antibodies play a critical role in protecting the body from infections; however, excessive antibody production is involved in the pathogenesis of autoimmune diseases and transplanted organ rejection. Regulation of antibody production is… read more here.
Keywords: antibody production; antibody; pi3k dgr;
Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.01.023
Abstract: Bioconjugation with polyethylene glycol (PEG) is important for protein drug development as it has improved biological stability. In contrast, proteins including PEGylated ones are susceptible to physicochemical stresses. Particularly, protein drugs in solution may form… read more here.
Keywords: peg ova; dropping stress; subvisible particles; antibody production ... See more keywords
Immunisation - Choice of host, adjuvants and boosting schedules with emphasis on polyclonal antibody production.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.01.002
Abstract: Polyclonal antibodies are frequently used as immunodiagnostic tools in fundamental research. They are also used for routine diagnostic purposes in human and veterinary medicine and for quality control procedures in the food-processing industry. The antibody… read more here.
Keywords: antibody production; medicine; antibody; polyclonal antibody ... See more keywords
Aptamer as a Versatile Molecular Tool for Antibody Production Monitoring and Quality Control.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b13370
Abstract: Antibody drugs have been used to treat many diseases, and to date, this has been the most rapidly growing drug class. However, the lack of suitable methods for real-time and high-throughput monitoring of antibody production… read more here.
Keywords: antibody production; quality control; antibody;
Hapten synthesis and antibody production for the development of a paper immunosensor for lean meat powder zilpaterol
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj00426c
Abstract: An anti-zilpaterol mAb with an IC50 of 0.31 ng mL−1 and a limit of detection (LOD) of 0.02 ng mL−1 has been developed. For semi-quantitative detection in pork samples, the visual LOD is 0.5 ng… read more here.
Keywords: hapten synthesis; synthesis antibody; development paper; production development ... See more keywords
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217902120
Abstract: Significance A major gap in our current knowledge of COVID-19 is our limited understanding of the pathways of antibody production during acute disease. While a key pathway of antibody production driven by T-follicular helper cells… read more here.
Keywords: antibody production; covid patients; sex biased; biased imbalance ... See more keywords
AbDesigner3D: a structure‐guided tool for peptide‐based antibody production
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty055
Abstract: Summary: We present AbDesigner3D, a new tool for identification of optimal immunizing peptides for antibody production using a peptide‐based strategy. AbDesigner3D integrates 3D structural data from the Protein Data Bank (PDB) with UniProt data, which… read more here.
Keywords: antibody production; peptide based; abdesigner3d; tool ... See more keywords
Differential effects of experimental hyperthyroidism on declined immunity of broiler chicken
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Animal Physiology and Animal Nutrition"
DOI: 10.1111/jpn.12861
Abstract: Thyroid hormones (THs) are involved in the development of lymphoid organs and regulation of immune function in birds. However, their role as an immune-modulator in the hyperthyroid state is still debatable. To explore the interrelationship… read more here.
Keywords: antibody production; hyperthyroidism; production; response ... See more keywords
Commentary on: Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14492
Abstract: Antiphospholipid syndrome (APS) has been an enigma for many years. The diagnosis of a patient is based on rather generally occur‐ ring clinical symptoms in combination with specific laboratory tests. In more detail, as stated… read more here.
Keywords: antibody production; production; treatment; antiphospholipid antibody ... See more keywords