Characterization of Antibody Products Obtained through Enzymatic and Nonenzymatic Glycosylation Reactions with a Glycan Oxazoline and Preparation of a Homogeneous Antibody-Drug Conjugate via Fc N-Glycan.
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DOI: 10.1021/acs.bioconjchem.9b00132
Abstract: Glycan engineering of antibodies has received considerable attention. Although various endo-β- N-acetylglucosaminidase mutants have been developed for glycan remodeling, a side reaction has been reported between glycan oxazoline and amino groups. In this study, we… read more here.
Keywords: antibody; characterization antibody; drug; glycan oxazoline ... See more keywords
Cardiovascular Adverse Events Associated with Monoclonal Antibody Products in Patients with COVID-19
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DOI: 10.3390/ph15121472
Abstract: Little is known about cardiovascular safety profiles for monoclonal antibody products that received the FDA Emergency Use Authorization for COVID-19. In this study, data from the FDA Adverse Event Reporting System from the first quarter… read more here.
Keywords: safety; monoclonal antibody; antibody products; bamlanivimab ... See more keywords