Chromatin-directed clarification in cell culture fluid enables non-protein affinity antibody purification by tangential flow filtration integrated with high-capacity cation exchange chromatography
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DOI: 10.1016/j.bej.2019.107315
Abstract: Abstract Traditional purification platforms for monoclonal antibodies (mAbs) rely heavily on 3–4 step chromatographic operations with protein A affinity chromatography as the essential antibody capture approach. In this study, we applied for the first time… read more here.
Keywords: purification; antibody purification; chromatin directed; antibody ... See more keywords
A general platform for antibody purification utilizing engineered-micelles
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DOI: 10.1080/19420862.2019.1565749
Abstract: ABSTRACT We introduce a new concept and potentially general platform for antibody (Ab) purification that does not rely on chromatography or specific ligands (e.g., Protein A); rather, it makes use of detergent aggregates capable of… read more here.
Keywords: platform antibody; antibody purification; engineered micelles; general platform ... See more keywords