Fc‐Binding Antibody‐Recruiting Molecules Targeting Prostate‐Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement **
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DOI: 10.1002/cbic.202000577
Abstract: Synthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of therapeutic antibodies, such as immunogenicity and the need for intravenous delivery. Previously, we reported… read more here.
Keywords: prostate; recruiting molecules; antibody; antibody recruiting ... See more keywords
A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00187
Abstract: Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for the treatment of cancer. Here, the first radiolabeled antibody-recruiting small molecule that… read more here.
Keywords: antibody; radiolabeled antibody; versatile platform; antibody recruiting ... See more keywords
Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria†
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DOI: 10.1039/c9sc04842a
Abstract: Antibiotic resistant infections are projected to cause over 10 million deaths by 2050, yet the development of new antibiotics has slowed. This points to an urgent need for methodologies for the rapid development of antibiotics… read more here.
Keywords: antibiotic resistant; recruiting protein; antibody recruiting; catalyzed capture ... See more keywords
Sequence-defined antibody-recruiting macromolecules
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DOI: 10.1039/d3sc01507f
Abstract: Antibody-recruiting molecules represent a novel class of therapeutic agents that mediate the recruitment of endogenous antibodies to target cells, leading to their elimination by the immune system. Compared to single-ligand... read more here.
Keywords: sequence defined; recruiting macromolecules; antibody recruiting; antibody ... See more keywords