In Vitro Generation of Human Antibody-Secreting Cells Through the Stimulation of PBMCs with Dengue Virus Particles.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1879-0_16
Abstract: The Dengue pathophysiology has had several aspects determined over the years. However, some points remain elusive, such as the metabolic factors that regulate the massive B cell differentiation into antibody-secreting cells observed in Dengue patients.… read more here.
Keywords: secreting cells; antibody secreting; dengue virus;
Isolation of Antigen-Specific, Antibody-Secreting Cells Using a Chip-Based Immunospot Array.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8958-4_6
Abstract: Antigen-specific monoclonal antibodies are useful tools to detect very small amounts of antigenic materials and are applicable for antibody therapeutics. To produce mouse monoclonal antibodies, a hybridoma between B lymphocytes and myeloma cells is used… read more here.
Keywords: antibody secreting; monoclonal antibodies; specific antibody; antigen specific ... See more keywords
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.04.004
Abstract: Although viral infections elicit robust interferon-γ (IFN-γ) and long-lived antibody-secreting cell (ASC) responses, the roles for IFN-γ and IFN-γ-induced transcription factors (TFs) in ASC development are unclear. We showed that B cell intrinsic expression of… read more here.
Keywords: transcription; antibody secreting; ifn; ifn induced ... See more keywords
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
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DOI: 10.1038/s41598-018-32705-7
Abstract: The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified… read more here.
Keywords: secreting cells; antibody secreting; secretory; site ... See more keywords
High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen
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DOI: 10.1038/s41598-018-32926-w
Abstract: IgM antibodies (Abs) are thought to play a major role in humoral immunity but only at the early stage of the primary immune response. However, two subsets of IgM+ memory B cells (MBCs), one with… read more here.
Keywords: antibody secreting; high affinity; affinity; memory cells ... See more keywords
B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction
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DOI: 10.1111/acel.13692
Abstract: Vaccines typically protect against (re)infections by generating pathogen‐neutralising antibodies. However, as we age, antibody‐secreting cell formation and vaccine‐induced antibody titres are reduced. Antibody‐secreting plasma cells differentiate from B cells either early post‐vaccination through the extrafollicular… read more here.
Keywords: cell; age; antibody secreting; formation ... See more keywords
THU0241 LUPUS PROGRESSION IS PREVENTED BY TREATMENT WITH VERDINEXOR, AN INHIBITOR OF THE NUCLEAR EXPORT PROTEIN EXPORTIN-1, BY LIMITING GERMINAL CENTER FORMATION AND DEVELOPMENT OF AUTOREACTIVE ANTIBODY SECRETING CELLS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3092
Abstract: Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by simultaneous activation of the innate and adaptive arms of the immune system. Recently the nuclear export protein exportin-1 (XPO1) has surfaced as an… read more here.
Keywords: antibody secreting; verdinexor; sine compounds; nuclear export ... See more keywords
Diagnosis of Mycoplasma pneumoniae Pneumonia with Measurement of Specific Antibody-Secreting Cells
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DOI: 10.1164/rccm.201904-0860le
Abstract: Mycoplasma pneumoniae (Mp) is reported to be the most common bacterial cause of community-acquired pneumonia (CAP) in hospitalized U.S. children (1). However, current diagnostic tests, including PCR of upper respiratory tract (URT) specimens and serology,… read more here.
Keywords: patients cap; antibody secreting; mycoplasma pneumoniae; antibody ... See more keywords
Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells
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DOI: 10.1371/journal.pone.0259644
Abstract: Background Streptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to introduce definitive therapy potentially improving patient outcomes. Methods We introduce two new methods for diagnosing… read more here.
Keywords: antibody secreting; pneumoniae infections; secreting cells; pneumoniae ... See more keywords
Impaired Circulating Antibody-Secreting Cells Generation Predicts the Dismal Outcome in the Elderly Septic Shock Patients
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DOI: 10.2147/jir.s376962
Abstract: Purpose Sepsis is a condition that derives from a dysregulated host response to infection. Although B lymphocytes play a pivotal role in immune response, little is known about status of their terminally differentiated cells, antibody-secreting… read more here.
Keywords: secreting cells; elderly septic; septic shock; shock patients ... See more keywords
CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00032
Abstract: CD11c+ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c+ B cells from healthy donors by… read more here.
Keywords: secreting cells; antibody secreting; cells healthy; cd11c cells ... See more keywords