Following nature's roadmap: folding factors from plasma cells led to improvements in antibody secretion in S. cerevisiae.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201600631
Abstract: Therapeutic protein production in yeast is a reality in industry with an untapped potential to expand to more complex proteins, such as full-length antibodies. Despite numerous engineering approaches, cellular limitations are preventing the use of… read more here.
Keywords: antibody; antibody secretion; plasma cells; yeast ... See more keywords
The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859598
Abstract: Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we… read more here.
Keywords: mist1; plasma cells; expression; plasma ... See more keywords