A photoresponsive antibody–siRNA conjugate for activatable immunogene therapy of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc01672a
Abstract: Tumor-targeted delivery of small-interfering RNAs (siRNAs) for cancer therapy still remains a challenging task. While antibody–siRNA conjugates (ARCs) provide an alternative way to address this challenge, the uncontrollable siRNA release potentially leads to undesirable off-tumor… read more here.
Keywords: immunogene therapy; therapy; photoresponsive antibody; cancer ... See more keywords
Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2017.1273344
Abstract: ABSTRACT Introduction: Generating effective RNAi-based therapies with the potential to achieve leukemia remission remains critical unmet need. Despite a growing number of leukemia clinical trials, tissue specific delivery of therapeutic siRNA is a major roadblock… read more here.
Keywords: therapy antibody; sirna conjugates; antibody sirna; leukemic therapy ... See more keywords