Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr06512a
Abstract: Monitoring malignant progression and disease recurrence post-therapy are central challenges to improving the outcomes of patients with multiple myeloma (MM). Whereas current detection methods that rely upon bone marrow examination allow for precise monitoring of… read more here.
Keywords: targeting ultra; detection; antibody targeting; multiple myeloma ... See more keywords
Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17221
Abstract: Age-related macular degeneration (AMD) is one of the main causes of visual impairment in adults. Visual deterioration is more prominent in neovascular AMD with choroidal neovascularization (CNV). Clinical and postmortem studies suggested that complement system… read more here.
Keywords: targeting mg4; mg4 domain; antibody targeting; antibody ... See more keywords
Generation and Characterization of a Bispecific Antibody Targeting Both PD-1 and c-MET.
Sign Up to like & getrecommendations! Published in 2018 at "Protein and peptide letters"
DOI: 10.2174/0929866524666171017143753
Abstract: BACKGROUND Bispecific antibodies, BsAbs, are molecules with the ability to bind to two different epitopes on the same or different antigens. c-MET, cellular-mesenchymal to epithelial transition factor, is deregulated in many types of human malignancies.… read more here.
Keywords: targeting met; antibody targeting; tumor cells; bispecific antibody ... See more keywords
N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.657008
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with extremely limited treatment; the effective targeting strategy stays an urgent unmet need. Neuropilin-2 (NRP2), a multifunctional transmembrane non-tyrosine-kinase glycoprotein, enhances various signal transduction pathways to… read more here.
Keywords: antibody targeting; fak erk; pancreatic ductal; ductal adenocarcinoma ... See more keywords
Antibody Targeting of Eph Receptors in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13050088
Abstract: The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells… read more here.
Keywords: eph receptors; antibody targeting; targeting eph; receptors cancer ... See more keywords
Advances in Antibody-Based Therapeutics for Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010145
Abstract: Cerebral ischemia is an acute disorder characterized by an abrupt reduction in blood flow that results in immediate deprivation of both glucose and oxygen. The main types of cerebral ischemia are ischemic and hemorrhagic stroke.… read more here.
Keywords: antibody targeting; antibody based; cerebral ischemia; antibody ... See more keywords