AZD1402/PRS-060, an inhaled Anticalin® IL-4Ra antagonist, potently inhibits IL-4 induced functional effects in human whole blood, which can be employed translationally in clinical studies
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa5248
Abstract: Introduction: AZD1402 is an Anticalin protein in clinical development that has the potential to offer an inhaled treatment for asthma patients suffering from T2-driven disease through selective blockade of IL-4Rα. Aims and objective: To characterise… read more here.
Keywords: potently inhibits; human whole; anticalin; whole blood ... See more keywords
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.38968
Abstract: Enhanced amino acid supply and dysregulated integrin signaling constitute two hallmarks of cancer and are pivotal for metastatic transformation of cells. In line with its function at the crossroads of both processes, overexpression of CD98hc… read more here.
Keywords: human cd98hc; affinity; cd98hc; anticalin ... See more keywords