Factors Associated With Patients Not Receiving Oral Anticancer Drugs
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DOI: 10.1001/jamanetworkopen.2022.36380
Abstract: Key Points Question How many patients with cancer do not receive oral anticancer drug prescriptions, and what are the factors associated with this failure to receive these drugs? Findings A cohort study of 1024 patients… read more here.
Keywords: anticancer drugs; anticancer drug; factors associated; anticancer ... See more keywords
Targeting senescence as an anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13312
Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.
Keywords: one two; senescence; senescent cells; anticancer ... See more keywords
Nanocomplexes of Biodegradable Anticancer Macromolecules: Prolonged Plasma Half-life, Reduced Toxicity, and Increased Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202201560
Abstract: Anticancer drug resistance is a large contributing factor to the global mortality rate of cancer patients. Anticancer macromolecules such as polymers were recently reported to overcome this issue. Anticancer macromolecules have unselective toxicity because they… read more here.
Keywords: toxicity; half; anticancer macromolecules; anticancer ... See more keywords
Antineoplastic Drug-Free Anticancer Strategy Enabled by Host-Defense-Peptides-Mimicking Synthetic Polypeptides.
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DOI: 10.1002/adma.202001108
Abstract: An antineoplastic drug-free anticancer strategy enabled by host defense peptides (HDPs)-mimicking synthetic polypeptides is reported. The polypeptide exhibits a broad spectrum of anticancer activity in 12 cancer cell lines, including drug-resistant and highly metastatic tumor… read more here.
Keywords: anticancer strategy; antineoplastic drug; drug; free anticancer ... See more keywords
Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepters
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DOI: 10.1002/adma.202211597
Abstract: The spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect of malignant tumors. Blocking interactive crosstalk in this fashion is significant but challenging. Herein, a communication interception strategy is reported,… read more here.
Keywords: subcellular organelles; spatiotemporal crosstalk; anticancer; therapy ... See more keywords
Recent advances in isatin hybrids as potential anticancer agents
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DOI: 10.1002/ardp.201900367
Abstract: The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in… read more here.
Keywords: based hybrids; anticancer agents; advances isatin; recent advances ... See more keywords
Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors
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DOI: 10.1002/ardp.202000491
Abstract: The anticancer activity of novel thiazolidine‐2,4‐diones was evaluated against HepG2, HCT‐116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive one to the cytotoxic effect of the new derivatives. In… read more here.
Keywords: hct 116; vegfr inhibitors; admet profile; anticancer ... See more keywords
Synthesis and biological evaluation of N4 -hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy.
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100213
Abstract: To obtain new anticancer agents with antimetastatic adjunct efficacy, a series of novel N4 -hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were designed and synthesized by an eight-step reaction, with appropriate yields. All the synthesized compounds were evaluated… read more here.
Keywords: pyrimidin one; pyrrolo pyrimidin; dihydro pyrrolo; adjunct efficacy ... See more keywords
The anticancer activity of carbazole alkaloids.
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DOI: 10.1002/ardp.202100277
Abstract: Chemotherapy is the first choice for the majority of cancers, but severe side effects and drug resistance restrict the actual clinical efficacy. Carbazole alkaloids, mainly from the Rutaceae family, possess favorable donor ability, good planarity,… read more here.
Keywords: anticancer; carbazole alkaloids; activity carbazole; anticancer activity ... See more keywords
Microwave‐assisted N‐alkylation of amines with alcohols catalyzed by MnCl2: Anticancer, docking, and DFT studies
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DOI: 10.1002/ardp.202100443
Abstract: A new protocol for the N‐alkylation of amines with alcohols for the synthesis of tertiary amines in the presence of MnCl2 as a catalyst, under microwave conditions, is described. The advantages of this protocol include… read more here.
Keywords: assisted alkylation; microwave assisted; amines alcohols; alkylation amines ... See more keywords
Synthesis of cinnamils and quinoxalines and their biological evaluation as anticancer agents
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DOI: 10.1002/ardp.202100448
Abstract: We synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for quinoxalines via condensation with 1,2‐diaminobenzene. Among the 26 synthesized compounds reported in this article, we found that cinnamil… read more here.
Keywords: cinnamils quinoxalines; quinoxalines biological; biological evaluation; synthesis cinnamils ... See more keywords