Synthesis, anticancer activity, and molecular modeling of etodolac‐thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
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DOI: 10.1002/ardp.201700195
Abstract: A series of (R,S)‐1‐{[5‐(substituted)sulfanyl‐4‐substituted‐4H‐1,2,4‐triazole‐3‐yl]methyl}‐1,8‐diethyl‐1,3,4,9‐tetrahydropyrano[3,4‐b]indoles (5a–v) were designed and synthesized using a five‐step synthetic protocol that involves substituted benzyl chlorides and (R,S)‐5‐[(1,8‐diethyl‐1,3,4,9‐tetrahydropyrano[3,4‐b]indole‐1‐yl)methyl]‐4‐substituted‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones in the final step. The synthesized derivatives were evaluated for cytotoxicity and anticancer activity… read more here.
Keywords: molecular modeling; methionine aminopeptidase; anticancer activity; aminopeptidase type ... See more keywords
The anticancer activity of carbazole alkaloids.
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DOI: 10.1002/ardp.202100277
Abstract: Chemotherapy is the first choice for the majority of cancers, but severe side effects and drug resistance restrict the actual clinical efficacy. Carbazole alkaloids, mainly from the Rutaceae family, possess favorable donor ability, good planarity,… read more here.
Keywords: anticancer; carbazole alkaloids; activity carbazole; anticancer activity ... See more keywords
The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers
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DOI: 10.1002/ardp.202200086
Abstract: Cancer, the most significant cause of morbidity and mortality, has already posed a heavy burden on health care systems globally. In recent years, cancer treatment has made a significant breakthrough, but cancer cells inevitably acquire… read more here.
Keywords: anticancer activity; artemisinin derivatives; current scenario; anticancer ... See more keywords
Synthesis, density functional theory calculation, molecular docking studies, and evaluation of novel 5‐nitrothiophene derivatives for anticancer activity
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DOI: 10.1002/ardp.202200105
Abstract: Within the scope of this study, new 2‐{2‐[(5‐nitrothiophen‐2‐yl)methylene]hydrazinyl}thiazole derivatives (2a–j) were synthesized and investigated for their potential anticancer and enzyme inhibition activities. Spectroscopic techniques were used to determine the structures of substances. The anticancer activities… read more here.
Keywords: molecular docking; functional theory; anticancer activity; density functional ... See more keywords
New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity
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DOI: 10.1002/ardp.202200417
Abstract: New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth factor tyrosine kinase (EGFR‐TK) inhibition activities. Compound 24, which is characterized by a 2‐benzyl‐thio function,… read more here.
Keywords: compound; anticancer activity; inhibition; molecular modeling ... See more keywords
Anticancer Activity of Reconstituted Ribonuclease S‐Decorated Artificial Viral Capsid
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DOI: 10.1002/cbic.202200220
Abstract: Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S‐decorated… read more here.
Keywords: artificial viral; decorated artificial; anticancer activity; ribonuclease ... See more keywords
Synthesis and Structure of Naphthoyl Thiourea‐Based Binuclear Ruthenium(II) Arene Complexes: Studies on Anticancer Activity and Apoptotic Mechanism
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DOI: 10.1002/cbic.202500057
Abstract: Herein, the synthesis, characterization, and anticancer activity of ruthenium(II) p‐cymene complexes comprising naphthoyl thiourea‐based ligands are described. The synthesized N^O and N^S chelating ruthenium(II) complexes (1–3) are fully characterized by elemental analysis and spectral (fourier… read more here.
Keywords: ruthenium; thiourea based; anticancer activity; synthesis ... See more keywords
In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs
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DOI: 10.1002/cmdc.201800551
Abstract: Due to the toxicity of platinum compounds used in the clinic as anticancer chemotherapies, titanium serves as a safe and attractive alternative. Lately, we introduced a new family of Ti complexes based on readily available… read more here.
Keywords: vivo anticancer; platinum; anticancer activity; efficacy ... See more keywords
Machine Learning‐Driven QSAR Modeling of Anticancer Activity from a Rationally Designed Synthetic Flavone Library
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DOI: 10.1002/cmdc.202500143
Abstract: Flavones, recognized as "privileged scaffolds" in drug discovery, hold significant promise as anticancer agents. This study develops a quantitative structure–activity relationship (QSAR) model to accelerate the optimization of lead compounds. Using pharmacophore modeling against different… read more here.
Keywords: anticancer; driven qsar; anticancer activity; machine learning ... See more keywords
Exploring the Topoisomerase II Inhibitory Potential of Steroidal Drugs as a Recommended Mechanism of Action for Their Anticancer Activity: In Silico and In Vitro Assessments
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DOI: 10.1002/ddr.70152
Abstract: Herein, and based on the pharmacophoric features of doxorubicin (Dox); 133 steroids were screened to assess their ability to act as TOP II inhibitors for the discovery of those with promising anticancer activity. The cytotoxic… read more here.
Keywords: fusidic acid; fluticasone propionate; anticancer activity;
Synergistic Action of Rutin‐Coated Zinc Oxide Nanoparticles: Targeting Biofilm Formation Receptors of Dental Pathogens and Modulating Apoptosis Genes for Enhanced Oral Anticancer Activity
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DOI: 10.1002/jbt.70030
Abstract: Oral diseases are often associated with bacterial and fungal pathogens such as Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, and Candida albicans. This research explored a novel approach to addressing these pathogens by synthesizing zinc oxide… read more here.
Keywords: zinc oxide; anticancer activity; oxide nanoparticles; zno nps ... See more keywords