Synthesis, anticancer activity, and molecular modeling of etodolac‐thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
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DOI: 10.1002/ardp.201700195
Abstract: A series of (R,S)‐1‐{[5‐(substituted)sulfanyl‐4‐substituted‐4H‐1,2,4‐triazole‐3‐yl]methyl}‐1,8‐diethyl‐1,3,4,9‐tetrahydropyrano[3,4‐b]indoles (5a–v) were designed and synthesized using a five‐step synthetic protocol that involves substituted benzyl chlorides and (R,S)‐5‐[(1,8‐diethyl‐1,3,4,9‐tetrahydropyrano[3,4‐b]indole‐1‐yl)methyl]‐4‐substituted‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones in the final step. The synthesized derivatives were evaluated for cytotoxicity and anticancer activity… read more here.
Keywords: molecular modeling; methionine aminopeptidase; anticancer activity; aminopeptidase type ... See more keywords
The anticancer activity of carbazole alkaloids.
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DOI: 10.1002/ardp.202100277
Abstract: Chemotherapy is the first choice for the majority of cancers, but severe side effects and drug resistance restrict the actual clinical efficacy. Carbazole alkaloids, mainly from the Rutaceae family, possess favorable donor ability, good planarity,… read more here.
Keywords: anticancer; carbazole alkaloids; activity carbazole; anticancer activity ... See more keywords
The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers
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DOI: 10.1002/ardp.202200086
Abstract: Cancer, the most significant cause of morbidity and mortality, has already posed a heavy burden on health care systems globally. In recent years, cancer treatment has made a significant breakthrough, but cancer cells inevitably acquire… read more here.
Keywords: anticancer activity; artemisinin derivatives; current scenario; anticancer ... See more keywords
Synthesis, density functional theory calculation, molecular docking studies, and evaluation of novel 5‐nitrothiophene derivatives for anticancer activity
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DOI: 10.1002/ardp.202200105
Abstract: Within the scope of this study, new 2‐{2‐[(5‐nitrothiophen‐2‐yl)methylene]hydrazinyl}thiazole derivatives (2a–j) were synthesized and investigated for their potential anticancer and enzyme inhibition activities. Spectroscopic techniques were used to determine the structures of substances. The anticancer activities… read more here.
Keywords: molecular docking; functional theory; anticancer activity; density functional ... See more keywords
New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity
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DOI: 10.1002/ardp.202200417
Abstract: New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth factor tyrosine kinase (EGFR‐TK) inhibition activities. Compound 24, which is characterized by a 2‐benzyl‐thio function,… read more here.
Keywords: compound; anticancer activity; inhibition; molecular modeling ... See more keywords
Anticancer Activity of Reconstituted Ribonuclease S‐Decorated Artificial Viral Capsid
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DOI: 10.1002/cbic.202200220
Abstract: Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S‐decorated… read more here.
Keywords: artificial viral; decorated artificial; anticancer activity; ribonuclease ... See more keywords
In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs
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DOI: 10.1002/cmdc.201800551
Abstract: Due to the toxicity of platinum compounds used in the clinic as anticancer chemotherapies, titanium serves as a safe and attractive alternative. Lately, we introduced a new family of Ti complexes based on readily available… read more here.
Keywords: vivo anticancer; platinum; anticancer activity; efficacy ... See more keywords
Design, Synthesis, and Anticancer Activity of 3H–benzo[f]chromen-3-one Derivatives
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DOI: 10.1002/jhet.2853
Abstract: A series of substituted aminomethylbenzocoumarin derivatives 8a–i have been synthesized, characterized, and structure of compound 8g was confirmed by X-ray single crystal analysis. All the synthesized compounds were tested for their anticancer activity against cancer… read more here.
Keywords: cell; activity; cell line; anticancer activity ... See more keywords
Synthesis and anticancer activity evaluation of new isoindole analogues
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DOI: 10.1007/s00044-017-1793-1
Abstract: We have developed a versatile synthetic approach for the synthesis of new isoindole derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo-cycloadduct prepared from the Diels–Alder reaction of furan and maleic… read more here.
Keywords: new isoindole; isoindole derivatives; cell; anticancer activity ... See more keywords
Enhanced anticancer activity of combined treatment of imatinib and dipyridamole in solid Ehrlich carcinoma-bearing mice
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DOI: 10.1007/s00210-019-01803-2
Abstract: The current study was designed to evaluate potential enhancement of the anticancer activity of imatinib mesylate (IM) with dipyridamole (DIP) and to investigate the underlying mechanisms of the combined therapy (IM/DIP) to reduce hepatotoxicity of… read more here.
Keywords: combination; anticancer activity; dip; solid ehrlich ... See more keywords
Contribution of reactive oxygen species to the anticancer activity of aminoalkanol derivatives of xanthone
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DOI: 10.1007/s10637-017-0537-x
Abstract: SummaryReactive oxygen species (ROS) are critically involved in the action of anticancer agents. In this study, we investigated the role of ROS in the anticancer mechanism of new aminoalkanol derivatives of xanthone. Most xanthones used… read more here.
Keywords: derivatives xanthone; oxygen species; anticancer activity; aminoalkanol derivatives ... See more keywords