Three-dimensional coordination polymers based on trimethyltin cation with nicotinic and isonicotinic acids as anticancer agents
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DOI: 10.1002/aoc.4066
Abstract: Two new coordination polymers, namely [Me3Sn(INA)] (CP1) and [Me3Sn(NA)] (CP2), where INA = isonicotinic acid and NA = nicotinic acid, were characterized using infrared, UV–visible and NMR spectroscopies, thermogravimetric analysis and single-crystal X-ray analyses. The structure of CP1 consists… read more here.
Keywords: three dimensional; cp2; coordination polymers; anticancer agents ... See more keywords
Design, synthesis, and biological evaluation of novel 3‐(thiophen‐2‐ylthio)pyridine derivatives as potential multitarget anticancer agents
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DOI: 10.1002/ardp.201900024
Abstract: A series of novel 3‐(thiophen‐2‐ylthio)pyridine derivatives as insulin‐like growth factor 1 receptor (IGF‐1R) inhibitors was designed and synthesized. IGF‐1R kinase inhibitory activities and cytotoxicities against HepG2 and WSU‐DLCL2 cell lines were tested. For all of… read more here.
Keywords: ylthio pyridine; novel thiophen; anticancer agents; multitarget anticancer ... See more keywords
Recent advances in isatin hybrids as potential anticancer agents
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DOI: 10.1002/ardp.201900367
Abstract: The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in… read more here.
Keywords: based hybrids; anticancer agents; advances isatin; recent advances ... See more keywords
Current perspectives on naturally occurring saponins as anticancer agents
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DOI: 10.1002/ardp.202100469
Abstract: Saponins, a heterogeneous group of sterol and triterpene glycosides, are distributed widely in nature. Naturally occurring saponins could act on diverse targets in cancer cells and consequently exert potential antiproliferative effects in various cancers, including… read more here.
Keywords: perspectives naturally; current perspectives; anticancer agents; saponins anticancer ... See more keywords
Cinnamic acid hybrids as anticancer agents: A mini‐review
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DOI: 10.1002/ardp.202200052
Abstract: Cancer, as a long‐lasting and dramatic disease, affects almost one‐third of human beings globally. Chemotherapeutics play an important role in cancer treatment, but multidrug resistance and severe adverse effects have already become the main causes… read more here.
Keywords: cancer; hybrids anticancer; acid; cinnamic acid ... See more keywords
Synthesis of selenophene‐based chalcone analogs and assessment of their biological activity as anticancer agents
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DOI: 10.1002/ardp.202200486
Abstract: Selenium is an essential micronutrient that is beneficial to human health. Selenium‐containing drugs have been developed as antioxidants, anti‐inflammatory, and anticancer agents. However, the synthesis of selenium‐containing chalcones has not been fully explored. Therefore, we… read more here.
Keywords: selenophene based; chalcone analogs; anticancer; anticancer agents ... See more keywords
Sulfonamide Inhibitors of β‐Catenin Signaling as Anticancer Agents with Different Output on c‐MYC
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DOI: 10.1002/cmdc.202000594
Abstract: The Wnt/β‐catenin pathway is often found deregulated in cancer. The aberrant accumulation of β‐catenin in the cell nucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treatments have… read more here.
Keywords: inhibitors catenin; anticancer agents; catenin signaling; sulfonamide inhibitors ... See more keywords
Anticancer Agents Derived from Cyclic Thiosulfonates: Structure‐Reactivity and Structure‐Activity Relationships
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DOI: 10.1002/cmdc.202200165
Abstract: Reported are structure‐property‐function relationships associated with a class of cyclic thiosulfonate molecules—disulfide‐bond disrupting agents (DDAs)—with the ability to downregulate the Epidermal Growth Factor Receptor (HER) family in parallel and selectively induce apoptosis of EGFR+ or… read more here.
Keywords: cyclic thiosulfonates; structure; activity; reactivity ... See more keywords
Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα
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DOI: 10.1002/ddr.21976
Abstract: We herein report a new series of indole‐tethered pyrazoline derivatives as potent anticancer agents. A total of 12 compounds were designed and synthesized by conventional as well as microwave‐irradiated synthesis methods. The latter method results… read more here.
Keywords: anticancer agents; synthesis; topoisomerase; indole tethered ... See more keywords
Decision making for promising quinoline‐based anticancer agents through combined methodology
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DOI: 10.1002/jbt.22522
Abstract: During the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers the problem… read more here.
Keywords: methodology; anticancer agents; decision making; anticancer ... See more keywords
Synthesis, characterization and molecular docking studies of thiouracil derivatives as potent thymidylate synthase inhibitors and potential anticancer agents
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DOI: 10.1007/s11030-017-9776-1
Abstract: Thymidylate synthase (TS), one of folate-dependent enzymes, is a key and well-recognized target for anticancer agents. In this study, a series of 6-aryl-5-cyano thiouracil derivatives were designed and synthesized in accordance with essential pharmacophoric features… read more here.
Keywords: anti proliferative; anticancer agents; thymidylate synthase; thiouracil derivatives ... See more keywords