Recent advances of platinum-based anticancer complexes in combinational multimodal therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300253
Abstract: Platinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit their clinical applications. Thus, the exploration on appropriate methods and strategies to overcome… read more here.
Keywords: anticancer complexes; based anticancer; therapy; platinum drugs ... See more keywords
New activation mechanism for half-sandwich organometallic anticancer complexes† †Electronic supplementary information (ESI) available. CCDC 1420046–1420052 and 1569283. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc05058e
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc05058e
Abstract: Half-sandwich RhIII anticancer complexes with activated Cp* rings not only undergo sequential CH3 H–D exchange, but also react with biological dienes, generating RhI Diels–Alder adducts in aqueous media at ambient temperature. read more here.
Keywords: activation mechanism; half sandwich; anticancer complexes; new activation ... See more keywords
Spatial characterization of redox processes and speciation of Ru(III) anticancer complexes by 19F magnetic resonance imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04830b
Abstract: The application of CF3-labeled Ru(III) anticancer complexes to magnetic resonance (MR) imaging of tumour tissues is demonstrated. By combining anatomical chemical-shift selective (CHESS) imaging with 19F chemical-shift imaging (CSI) MR methods, we show that oxidation… read more here.
Keywords: magnetic resonance; iii anticancer; anticancer complexes; resonance imaging ... See more keywords
Thermodynamic Evaluation of the Interactions between Anticancer Pt(II) Complexes and Model Proteins
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DOI: 10.3390/molecules26082376
Abstract: In this work, we have analysed the binding of the Pt(II) complexes ([PtCl(4′-phenyl-2,2′:6′,2″-terpyridine)](CF3SO3) (1), [PtI(4′-phenyl-2,2′:6′,2″-terpyridine)](CF3SO3) (2) and [PtCl(1,3-di(2-pyridyl)benzene) (3)] with selected model proteins (hen egg-white lysozyme, HEWL, and ribonuclease A, RNase A). Platinum coordination compounds… read more here.
Keywords: model proteins; thermodynamic evaluation; anticancer complexes; binding mode ... See more keywords