Self‐Assembly of Copper Polypyridyl Supramolecular Metallopolymers to Achieve Enhanced Anticancer Efficacy
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201900036
Abstract: Abstract Self‐assembled functional supramolecular metallopolymers have demonstrated application potential in cancer therapy. Herein, a copper polypyridyl complex was found able to self‐assemble into a supramolecular metallopolymer driven by the intermolecular interactions, which could enhance the… read more here.
Keywords: achieve enhanced; supramolecular metallopolymers; copper polypyridyl; anticancer efficacy ... See more keywords
Comparative study of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn and their anticancer efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Materials Science"
DOI: 10.1007/s12034-017-1376-2
Abstract: Nanotechnology is an emerging field in science and technology, which can be applied to synthesize new materials at the nanoscale level. The present investigation aimed at comparing the synthesis, characterization and in vitro anticancer efficacy… read more here.
Keywords: silver gold; gold nanoparticles; anticancer efficacy; microscopy ... See more keywords
Enzyme/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethylchitosan for enhanced drug stability and anticancer efficacy
Sign Up to like & getrecommendations! Published in 2019 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2019.04.050
Abstract: Abstract For enhanced stability and anticancer efficacy, the 10-Hydroxycamptothecin (10-HCPT) structure based pH/enzyme responsive polymeric prodrug nanoparticles were constructed by conjugating 10-HCPT to carboxymethylchitosan (CMCS) via pH/enzyme sensitive succinyl linkage followed by ultrasonic dispersion. At… read more here.
Keywords: drug; anticancer efficacy; prodrug nanoparticles; stability anticancer ... See more keywords
Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01603
Abstract: A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytotoxic efficacy in cancer (ovarian, prostate… read more here.
Keywords: cancer; methylene indolin; chloroquinolin methylene; anticancer efficacy ... See more keywords
Anticancer efficacy of 6-thioguanine loaded chitosan nanoparticles with or without curcumin.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.117
Abstract: 6-Thioguanine encapsulated chitosan nanoparticles (6-TG-CNPs) were formulated by the ionic-gelation method. Morphologically, the 6-TG-CNPs were spherical in shape and showed mean size, PDI, zeta potential and entrapment efficiency of 261.63 ± 6.01 nm, 0.34 ± 0.10, +15.97 ± 0.46 mV and 44.27%, respectively.… read more here.
Keywords: cell viability; chitosan nanoparticles; anticancer efficacy; efficacy thioguanine ... See more keywords
Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant in Vivo Anticancer Efficacy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00679
Abstract: The aberrant activation of the phosphoinositide 3-kinase (PI3K) pathway is closely linked to the progression of various cancers, highlighting its significance as a target for cancer therapy. In contrast to conventional PI3K inhibitors, the selective… read more here.
Keywords: anticancer efficacy; protac degraders; vivo anticancer; significant vivo ... See more keywords
Regulating the Anticancer Efficacy of Sgc8-Combretastatin A4 Conjugates: A Case of Recognizing the Significance of Linker Chemistry for the Design of Aptamer-Based Targeted Drug Delivery Strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c03013
Abstract: The unique merits of aptamers, including specificity, high binding affinity, easy cell internalization, and rapid tissue accumulation abilities, have led aptamer-drug conjugates to evolve into one of the most attractive strategies for targeted drug delivery… read more here.
Keywords: drug; chemistry; linker; anticancer efficacy ... See more keywords
Enhanced anticancer efficacy of primed natural killer cells via coacervate-mediated exogenous interleukin-15 delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00876a
Abstract: Effective exogenous delivery of interleukin (IL)-15 to natural killer (NK) cells with subsequent anticancer efficacy could be a promising immune cell-based cancer immunotherapy. For the protection of encapsulated cargo IL-15 while maintaining its bioactivity under… read more here.
Keywords: natural killer; killer cells; anticancer efficacy; coa ... See more keywords
Structure-base design to explore the anticancer efficacy of organometallic Pt(II)- and Au(III)-N-heterocyclic carbene (NHC) complexes
Sign Up to like & getrecommendations! Published in 2024 at "New Journal of Chemistry"
DOI: 10.1039/d4nj02853h
Abstract: Cancer is one of the leading public health concerns globally; therefore it is required better drugs for treatment. Several strategies have been taken to improve the success of drug discovery.... read more here.
Keywords: design explore; anticancer efficacy; explore anticancer; efficacy organometallic ... See more keywords
Polyethylene glycol-mediated functionalization of nanodelivery systems for improving their pharmacokinetic profile and anticancer efficacy
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2024.2383413
Abstract: Abstract PEGylation has emerged as a promising adaptation in the architecture of nanodelivery systems to improve their physicochemical properties, stability, circulation time, passive targeting to tumor tissues, and anticancer efficacy. Owing to its heterogeneity, metastatic… read more here.
Keywords: anticancer efficacy; polyethylene glycol; nanodelivery systems; efficacy ... See more keywords
Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy.
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular research"
DOI: 10.1093/cvr/cvae084
Abstract: AIMS The anthracycline family of anticancer agents such as doxorubicin (DOX) can induce apoptotic death of cardiomyocytes and cause cardiotoxicity. We previously reported that DOX-induced apoptosis is accompanied by cardiomyocyte cell cycle-reentry. Cell cycle progression… read more here.
Keywords: anticancer efficacy; dox induced; cdk7; cardiotoxicity ... See more keywords