Self‐Assembly of Copper Polypyridyl Supramolecular Metallopolymers to Achieve Enhanced Anticancer Efficacy
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201900036
Abstract: Abstract Self‐assembled functional supramolecular metallopolymers have demonstrated application potential in cancer therapy. Herein, a copper polypyridyl complex was found able to self‐assemble into a supramolecular metallopolymer driven by the intermolecular interactions, which could enhance the… read more here.
Keywords: achieve enhanced; supramolecular metallopolymers; copper polypyridyl; anticancer efficacy ... See more keywords
Comparative study of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn and their anticancer efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Materials Science"
DOI: 10.1007/s12034-017-1376-2
Abstract: Nanotechnology is an emerging field in science and technology, which can be applied to synthesize new materials at the nanoscale level. The present investigation aimed at comparing the synthesis, characterization and in vitro anticancer efficacy… read more here.
Keywords: silver gold; gold nanoparticles; anticancer efficacy; microscopy ... See more keywords
Enzyme/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethylchitosan for enhanced drug stability and anticancer efficacy
Sign Up to like & getrecommendations! Published in 2019 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2019.04.050
Abstract: Abstract For enhanced stability and anticancer efficacy, the 10-Hydroxycamptothecin (10-HCPT) structure based pH/enzyme responsive polymeric prodrug nanoparticles were constructed by conjugating 10-HCPT to carboxymethylchitosan (CMCS) via pH/enzyme sensitive succinyl linkage followed by ultrasonic dispersion. At… read more here.
Keywords: drug; anticancer efficacy; prodrug nanoparticles; stability anticancer ... See more keywords
Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e01603
Abstract: A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytotoxic efficacy in cancer (ovarian, prostate… read more here.
Keywords: cancer; methylene indolin; chloroquinolin methylene; anticancer efficacy ... See more keywords
Anticancer efficacy of 6-thioguanine loaded chitosan nanoparticles with or without curcumin.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.01.117
Abstract: 6-Thioguanine encapsulated chitosan nanoparticles (6-TG-CNPs) were formulated by the ionic-gelation method. Morphologically, the 6-TG-CNPs were spherical in shape and showed mean size, PDI, zeta potential and entrapment efficiency of 261.63 ± 6.01 nm, 0.34 ± 0.10, +15.97 ± 0.46 mV and 44.27%, respectively.… read more here.
Keywords: cell viability; chitosan nanoparticles; anticancer efficacy; efficacy thioguanine ... See more keywords
Regulating the Anticancer Efficacy of Sgc8-Combretastatin A4 Conjugates: A Case of Recognizing the Significance of Linker Chemistry for the Design of Aptamer-Based Targeted Drug Delivery Strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c03013
Abstract: The unique merits of aptamers, including specificity, high binding affinity, easy cell internalization, and rapid tissue accumulation abilities, have led aptamer-drug conjugates to evolve into one of the most attractive strategies for targeted drug delivery… read more here.
Keywords: drug; chemistry; linker; anticancer efficacy ... See more keywords
Enhanced anticancer efficacy of primed natural killer cells via coacervate-mediated exogenous interleukin-15 delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00876a
Abstract: Effective exogenous delivery of interleukin (IL)-15 to natural killer (NK) cells with subsequent anticancer efficacy could be a promising immune cell-based cancer immunotherapy. For the protection of encapsulated cargo IL-15 while maintaining its bioactivity under… read more here.
Keywords: natural killer; killer cells; anticancer efficacy; coa ... See more keywords
Anticancer Efficacy of Self-Nanoemulsifying Drug Delivery System of Sunitinib Malate
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DOI: 10.1208/s12249-017-0826-x
Abstract: Sunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various “self-nanoemulsifying drug delivery systems (SNEDDS)” of SM were… read more here.
Keywords: drug; sunitinib malate; dissolution rate; anticancer efficacy ... See more keywords
Combination of cefotaxime and cisplatin specifically and selectively enhances anticancer efficacy in nasopharyngeal carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230227162532
Abstract: BACKGROUND HMOX1 has a dual role in cancers, especially involving chemoresistance. We demonstrate that cephalosporin antibiotics exert strong anticancer activity in nasopharyngeal carcinoma mainly via drastic upregulation of HMOX1. OBJECTIVES Cephalosporin antibiotics are commonly used… read more here.
Keywords: nasopharyngeal carcinoma; cisplatin; anticancer efficacy; carcinoma ... See more keywords
Tumor Size-Dependent Anticancer Efficacy of Chlorin Derivatives for Photodynamic Therapy
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DOI: 10.3390/ijms19061596
Abstract: Photodynamic therapy (PDT) with a suitable photosensitizer molecule is a promising anticancer treatment. We evaluated two chlorin molecules as potential photosensitizers, methyl pyropheophorbide a (MPPa) and N-methoxyl purpurinimide (NMPi), against A549 human lung adenocarcinoma cells… read more here.
Keywords: size; photodynamic therapy; anticancer efficacy; tumor ... See more keywords
Synthesis, Characterization and Anticancer Efficacy Evaluation of Benzoxanthone Compounds toward Gastric Cancer SGC-7901
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061970
Abstract: Three benzoxanthone derivatives were synthesized through a new photochemical strategy. The in vitro cytotoxic activity of these compounds was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and their partition coefficients (logP) were measured by shake flask… read more here.
Keywords: characterization anticancer; benzoxanthone; synthesis characterization; anticancer efficacy ... See more keywords