Improvement of the performance of anticancer peptides using a drug repositioning pipeline.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100417
Abstract: The use of anticancer peptides (ACPs) as an alternative/complementary strategy to conventional chemotherapy treatments has been shown to decrease drug resistance and/or severe side effects. However, the efficacy of the positively-charged ACP is inhibited by… read more here.
Keywords: drug repositioning; anticancer peptides; repositioning pipeline; drug ... See more keywords
CACPP: A Contrastive Learning-Based Siamese Network to Identify Anticancer Peptides Based on Sequence Only.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00297
Abstract: Anticancer peptides (ACPs) recently have been receiving increasing attention in cancer therapy due to their low consumption, few adverse side effects, and easy accessibility. However, it remains a great challenge to identify anticancer peptides via… read more here.
Keywords: cacpp contrastive; identify anticancer; anticancer peptides; contrastive learning ... See more keywords
Active Semisupervised Model for Improving the Identification of Anticancer Peptides
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c03132
Abstract: Cancer is one of the most dangerous threats to human health. Accurate identification of anticancer peptides (ACPs) is valuable for the development and design of new anticancer agents. However, most machine-learning algorithms have limited ability… read more here.
Keywords: active semisupervised; identification anticancer; anticancer peptides; model ... See more keywords
Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/c9bm02080b
Abstract: Anticancer peptides (ACPs) have gained significant attention in the past few years. Most ACPs only act toward intracellular targets. However, their low membrane penetrability often limits their anticancer efficacy. Here we developed a novel melittin-RADA28… read more here.
Keywords: delivery impermeable; melittin; delivery; anticancer peptides ... See more keywords
Accelerating the discovery of anticancer peptides targeting lung and breast cancers with the Wasserstein autoencoder model and PSO algorithm
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac320
Abstract: In the development of targeted drugs, anticancer peptides (ACPs) have attracted great attention because of their high selectivity, low toxicity and minimal non-specificity. In this work, we report a framework of ACPs generation, which combines… read more here.
Keywords: breast; lung; anticancer peptides; wasserstein autoencoder ... See more keywords
ACP_MS: prediction of anticancer peptides based on feature extraction
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac462
Abstract: Anticancer peptides (ACPs) are bioactive peptides with antitumor activity and have become the most promising drugs in the treatment of cancer. Therefore, the accurate prediction of ACPs is of great significance to the research of… read more here.
Keywords: anticancer peptide; anticancer peptides; prediction; peptide sequences ... See more keywords
Learning embedding features based on multi-sense-scaled attention architecture to improve the predictive performance of anticancer peptides.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab560
Abstract: MOTIVATION Anticancer peptides (ACPs) have recently emerged as effective anticancer drugs in cancer therapy. Machine-learning-based predictors have been developed to identify ACPs and achieve satisfactory performance. However, existing methods suffer from experience-based feature engineering, which… read more here.
Keywords: anticancer peptides; dataset; acpred laf; predictive performance ... See more keywords
MLACP: machine-learning-based prediction of anticancer peptides
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20365
Abstract: Cancer is the second leading cause of death globally, and use of therapeutic peptides to target and kill cancer cells has received considerable attention in recent years. Identification of anticancer peptides (ACPs) through wet-lab experimentation… read more here.
Keywords: machine; machine learning; anticancer peptides; mlacp machine ... See more keywords
Chemical Strategies towards the Development of Effective Anticancer Peptides.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230426111157
Abstract: Cancer is increasingly recognized as one of the primary causes of death and has become a multifaceted global health issue. Modern medical science has made significant advancements in the diagnosis and therapy of cancer over… read more here.
Keywords: chemical strategies; towards development; anticancer peptides; strategies towards ... See more keywords
The Potential Use of Anticancer Peptides (ACPs) in the Treatment of Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Current cancer drug targets"
DOI: 10.2174/1568009619666191111141032
Abstract: Peptides have acquired increasing interest as promising therapeutics, particularly as anti-cancer alternatives during the recent years. They have been reported to demonstrate incredible anti-cancer potentials due to its low manufacturing cost, ease of synthesis and… read more here.
Keywords: hepatocellular carcinoma; treatment hepatocellular; carcinoma; anticancer peptides ... See more keywords
Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19030919
Abstract: Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in… read more here.
Keywords: properties biological; anticancer peptides; therapeutic properties; benefits marine ... See more keywords