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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200051
Abstract: Cancer, characterized by a deregulation of the cell cycle which mainly results in a progressive loss of cellular differentiation and uncontrolled cellular growth, remains a prominent cause of death across the world. Almost all currently…
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Keywords:
structure activity;
anticancer properties;
activity relationship;
benzimidazole hybrids ... See more keywords
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Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4370-x
Abstract: Helicteres hirsuta Lour. (H. hirsuta) has been considered as a herbal medicine for the treatment of malaria and diabetes but limited studies have been conducted on its anticancer and antibacterial properties. In this study, the…
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Keywords:
helicteres hirsuta;
hirsuta lour;
anticancer properties;
vitro antibacterial ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.066
Abstract: A new ligand MHPIP (MHPIP = 2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthroline) and its three ruthenium (II) complexes [Ru(N-N)2(MHPIP)](ClO4)2 (N-N = phen: 1,10-phenanthroline 1; dmp = 2,9-dimethyl-1,10-phenanthroline 2; ttbpy = 4,4'-ditertiarybutyl-2,2'-bipyridine 3) were synthesized and characterized. The cytotoxic activity in vitro was studied by MTT method. The complexes 1-3…
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Keywords:
apoptosis;
synthesis anticancer;
anticancer properties;
hepg2 cells ... See more keywords
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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112308
Abstract: A series of novel isocombretapyridines were designed and synthesized based on a lead compound isocombretastatin A-4 (isoCA-4) by replacing 3,4,5-trimethoxylphenyl with substituent pyridine nucleus. The MTT assay results showed that compound 20a possessed the most…
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Keywords:
design synthesis;
properties isocombretapyridines;
compound 20a;
synthesis anticancer ... See more keywords
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Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173735
Abstract: The rhizome of the plant Atractylodes macrocephala Koidz is the major constituent of the Traditional Chinese Medicine Baizhu, frequently used to treat gastro-intestinal diseases. Many traditional medicine prescriptions based on Baizhu and the similar preparation…
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Keywords:
anti inflammatory;
medicine;
antioxidant anti;
inflammatory ... See more keywords
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Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.05.003
Abstract: Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated…
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Keywords:
cells derived;
improved anticancer;
anticancer properties;
mvs polycaprolactone ... See more keywords
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Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.01.003
Abstract: Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)2]2+ (1), [(piq)Ru(phen)2]2+ (2), and [(piq)Ru(DIP)2]2+ (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-diphenyl-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding…
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Keywords:
ruthenium;
cytotoxic anticancer;
dna;
anticancer properties ... See more keywords
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Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.02.005
Abstract: In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a…
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Keywords:
new non;
oxido vanadium;
non oxido;
anticancer properties ... See more keywords
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Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.03.052
Abstract: Graphical abstract Figure. No Caption available. HighlightsPharmacokinetic study of quassinoid glycoside was performed for the first time.Bruceoside A could serve as the precursor of the potent anticancer brusatol in vivo, rather than its direct deglycosylated…
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Keywords:
fructus bruceae;
study;
bruceoside;
anticancer properties ... See more keywords
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Published in 2019 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2018.12.001
Abstract: The aqueous cashew leaves extract obtained was investigated for the preparation of gold nanoparticle (AuNPs). The obtained AuNPs were characterized by UV–Visible spectroscopy, FTIR and XRD analysis. Results indicated that the green synthesized AuNPs showed…
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Keywords:
antimicrobial anticancer;
green synthesized;
vitro antimicrobial;
leaves extract ... See more keywords
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Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00730
Abstract: Two ferrocenyl derivatives, Fc-CA and Fc-FA, were synthesized by a condensation reaction between the amino ferrocene and hydroxycinnamic acids, that is, caffeic acid (CA) and ferulic acid (FA). The structures and purity of all compounds…
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Keywords:
antioxidant anticancer;
properties functionalized;
study;
free radical ... See more keywords