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   Articles with "anticancer therapeutics" as a keyword



PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

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recommendations! Published in 2020 at "Oncogene"

DOI: 10.1038/s41388-020-1336-y

Abstract: Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has emerged as a potential therapeutic strategy for cancer. PROTACs are heterobifunctional molecules consisting of one ligand for binding to a protein… read more here.

Keywords: anticancer therapeutics; targeting chimeras; proteolysis targeting; protacs ... See more keywords

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

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recommendations! Published in 2019 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2020.1690449

Abstract: ABSTRACT Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the expression of their target genes by reducing mRNA stability and/or inhibiting translation. miRNAs are known to be aberrantly regulated in cancers. Modulators of… read more here.

Keywords: cancer; advances discovery; target effects; anticancer therapeutics ... See more keywords

Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.892914

Abstract: 12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs. Characterization was… read more here.

Keywords: anticancer therapeutics; identification linomide; docking studies; anticancer ... See more keywords

Harnessing Phytochemicals to Modulate the Nonsense-mediated Decay Pathway for Anticancer Drug Discovery

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recommendations! Published in 2025 at "Research Journal of Pharmacy and Technology"

DOI: 10.52711/0974-360x.2025.00074

Abstract: Cancer continues to be one of the major causes of human mortality across the globe. Current treatment options are not sufficient enough to control deaths caused by cancers and due to this there is high… read more here.

Keywords: nonsense mediated; harnessing phytochemicals; mediated decay; anticancer therapeutics ... See more keywords