PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1336-y
Abstract: Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has emerged as a potential therapeutic strategy for cancer. PROTACs are heterobifunctional molecules consisting of one ligand for binding to a protein… read more here.
Keywords: anticancer therapeutics; targeting chimeras; proteolysis targeting; protacs ... See more keywords
Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2020.1690449
Abstract: ABSTRACT Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the expression of their target genes by reducing mRNA stability and/or inhibiting translation. miRNAs are known to be aberrantly regulated in cancers. Modulators of… read more here.
Keywords: cancer; advances discovery; target effects; anticancer therapeutics ... See more keywords
Identification of Linomide Derivatives as Potential Anticancer Therapeutics using Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.892914
Abstract: 12 analogs bearing a structural similarity to Linomide, a bonafide anticancer agent were synthesized wherein cyclization of substituted dianilides rendered 4-hydroxyquinolin-2(1H)-ones that were subjected to a Mannich reaction to yield 4-hydroxy-3-(substituted-1-ylmethyl) quinolin-2(1H)-one analogs. Characterization was… read more here.
Keywords: anticancer therapeutics; identification linomide; docking studies; anticancer ... See more keywords