Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.05.008
Abstract: The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant… read more here.
Keywords: degradation; anticancer therapies; resistance targeted; resistance ... See more keywords
P17.28.A TUMORAL INTERFERON BETA INDUCES AN IMMUNE-STIMULATORY PHENOTYPE IN TUMOR-ASSOCIATED MACROPHAGES IN MELANOMA BRAIN METASTASES
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae144.315
Abstract: Type I interferons (IFN) such as IFNβ are pro-inflammatory cytokines involved in antiviral immune responses. Increasing evidence indicates that the success of several anticancer therapies, including radiotherapy, relies on the immune-stimulatory effects of type I… read more here.
Keywords: immune stimulatory; type; anticancer therapies; tumor ... See more keywords
Abstract 2688: Age-associated changes in macrophage function and phenotype affects cancer development, and the efficacy of macrophage targeted anticancer therapies in murine melanoma model
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2688
Abstract: Introduction: Aging of the immune system is a critical risk factor for chronic diseases, including cancer. Globally, cancer incidence is higher between 45 to 75 years of age and declines thereafter. However, the implications of… read more here.
Keywords: age; cancer; function; anticancer therapies ... See more keywords
Review and Prospect of Tissue-agnostic targeted Strategies in Anticancer therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200616143247
Abstract: Due to the increasing prevalence of cancer year by year, and the complexity and refractory nature of the disease itself, it is required to constantly innovate the development of new cancer treatment schemes. At the… read more here.
Keywords: anticancer therapies; targeted therapy; tissue agnostic; review prospect ... See more keywords
The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.570108
Abstract: Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells. On the one hand, cells expressing RAS genes (such as K-RAS, H-RAS)… read more here.
Keywords: anticancer therapies; macropinocytosis; macropinocytosis cancers; cancer cells ... See more keywords
The Role of ROS as a Double-Edged Sword in (In)Fertility: The Impact of Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061585
Abstract: Simple Summary Tumor cells are highly resistant to oxidative stress, but beyond a certain threshold, it may lead to apoptosis/necrosis. Thus, induced loss of redox balance can be a strategy used in anticancer therapies. However,… read more here.
Keywords: role ros; adverse effects; fertility; ros mediated ... See more keywords
Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes14010055
Abstract: Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota–drug interactions have been extensively investigated, but… read more here.
Keywords: microbiota pointed; microbiota; pharmacomicrobiomics anticancer; gut microbiota ... See more keywords
Combination Anticancer Therapies Using Selected Phytochemicals
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175452
Abstract: Cancer is still one of the most widespread diseases globally, it is considered a vital health challenge worldwide and one of the main barriers to long life expectancy. Due to the potential toxicity and lack… read more here.
Keywords: therapies using; combination anticancer; selected phytochemicals; anticancer ... See more keywords
Cardiotoxicity Induced by Anticancer Therapies: A Call for Integrated Cardio-Oncology Practice
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18091399
Abstract: The introduction of novel oncologic therapies, including targeted agents, immunotherapies, and antibody–drug conjugates, has transformed the therapeutic landscape of cancer care. This evolution has resulted in a dual clinical scenario; while survival outcomes have markedly… read more here.
Keywords: oncology; cardiotoxicity induced; cardiotoxicity; induced anticancer ... See more keywords
Cutting-Edge Advances in Anticancer Therapies: Insights from the Third Edition of the Special Issue “Novel Anticancer Strategies”
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17010054
Abstract: Cancer incidence and mortality continue to rise at an alarming rate worldwide, underscoring the urgent need for more effective therapeutic interventions [...]. read more here.
Keywords: cutting edge; therapies insights; insights third; advances anticancer ... See more keywords
Comparative Analysis of Adverse Effects: Protein Kinase Inhibitors Versus Traditional Anticancer Therapies
Sign Up to like & getrecommendations! Published in 2025 at "Scientia Pharmaceutica"
DOI: 10.3390/scipharm93020020
Abstract: The adverse effects of protein kinase inhibitors (PKIs) and other anticancer therapies were compared using FDA Adverse Events Reporting System (FAERS) data. The dataset included 159 FDA-approved anticancer drugs (71 PKIs, 88 nonPKIs) and analyzed… read more here.
Keywords: protein kinase; effects protein; adverse effects; kinase inhibitors ... See more keywords