Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
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DOI: 10.1021/acs.jmedchem.1c01207
Abstract: DCN1, a co-E3 ligase, interacts with UBC12 and activates cullin-RING ligases (CRLs) by catalyzing cullin neddylation. Although DCN1 has been recognized as an important therapeutic target for human diseases, its role in the cardiovascular area… read more here.
Keywords: dcn1 ubc12; anticardiac fibrotic; dcn1; discovery potent ... See more keywords