Anticholinergic drug usage and cognitive impairment: findings from three large European cohort studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09415-9
Abstract: Neurologists are familiar with the use of anticholinergic drugs for a variety of conditions including nausea and vomiting, vertigo and bladder dysfunction, a range of indications that reflects the wide distribution of acetylcholine receptors—muscarinic and… read more here.
Keywords: three large; cognitive impairment; anticholinergic drugs; large european ... See more keywords
The cognitive effects of anticholinergic drugs on apolipoprotein ε4 carriers and noncarriers in the Wisconsin Registry for Alzheimer's Prevention study.
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychology"
DOI: 10.1037/neu0000713
Abstract: OBJECTIVES The purpose of the study was to test the hypothesis that anticholinergic drug exposure is associated with cognitive decline in the Wisconsin Registry for Alzheimer's Prevention (WRAP) study. Secondary aims were to assess if… read more here.
Keywords: apolipoprotein carriers; wisconsin registry; study; drug ... See more keywords
The anticholinergic drug oxybutynin inhibits voltage‐dependent K+ channels in coronary arterial smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13138
Abstract: This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage‐dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration‐dependent manner, with an IC50 value… read more here.
Keywords: oxybutynin; voltage dependent; dependent channels; anticholinergic drug ... See more keywords
Audit of anticholinergic medication changes in older hospitalised patients using the Anticholinergic Drug Scale
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DOI: 10.1111/imj.13402
Abstract: In patients discharged from an Older Person's Health hospital, we assessed (i) the prevalence of anticholinergic medications (ACM) in this study population and (ii) changes in anticholinergic drug burden during admission using the Anticholinergic Drug… read more here.
Keywords: drug scale; using anticholinergic; drug; anticholinergic drug ... See more keywords
Anticholinergic Drug Use on Admission and the Risk of In-Hospital Falls in Older Hospitalized Patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Interventions in Aging"
DOI: 10.2147/cia.s357818
Abstract: Purpose In-hospital falls, especially among older patients, are a major and underestimated problem. Several studies have suggested a possible association between anticholinergic drug use and falls, but the results are inconclusive and studies focusing on… read more here.
Keywords: hospital falls; anticholinergic drug; drug use; drug ... See more keywords