Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1,3,4‐oxadiazole derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200294
Abstract: Two new series of 1,3,4‐oxadiazoles bearing pyridine and thiazole heterocycles (4a‐h and 5a‐h) were synthesized (2,5‐disubstituted‐1,3,4‐oxadiazoles). The structures of these newly synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, high‐resolution mass… read more here.
Keywords: molecular docking; activity molecular; molecular dynamic; anticholinesterase activity ... See more keywords
Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives.
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DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with… read more here.
Keywords: amine; amine derivatives; synthesis anticholinesterase; anticholinesterase activity ... See more keywords
Chemical composition of Helietta parvifolia and its in vitro anticholinesterase activity
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DOI: 10.1080/14786419.2017.1410808
Abstract: Abstract The chemical composition of the essential oil and the n-hexane (Hex), Ethyl Acetate (EtOAc) and butanol (BuOH) extracts from the leaves of Helietta parvifolia were determined by detailed GC-MS analysis, spectroscopic and spectrometric data.… read more here.
Keywords: anticholinesterase activity; chemical composition; composition; activity ... See more keywords
Essential oil of Cymbopogon citratus cultivated in Egypt: seasonal variation in chemical composition and anticholinesterase activity.
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DOI: 10.1080/14786419.2020.1713125
Abstract: The yield of essential oil obtained by hydrodistillation of Cymbopogon citratus fresh leaves ranged from 0.15% to 0.46% w/w; being the highest in spring and the lowest in winter. The oil sample obtained in winter… read more here.
Keywords: essential oil; cymbopogon citratus; anticholinesterase activity; activity ... See more keywords
Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies
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DOI: 10.3390/plants11233286
Abstract: Alzheimer’s disease remains a global health challenge and an unmet need requiring innovative approaches to discover new drugs. The current study aimed to investigate the inhibitory activity of Albizia lucidior and Albizia procera leaves against… read more here.
Keywords: molecular docking; budmunchiamine alkaloids; anticholinesterase activity; budmunchiamine ... See more keywords