Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808262
Abstract: Nucleic acid aptamers selected for thrombin binding have been previously shown to possess anticoagulant activity; however, problems with rapid renal clearance and short circulation half-life have prevented translation to clinical usefulness. Here, a family of… read more here.
Keywords: rna origami; anticoagulant activity; rna; dna ... See more keywords
Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications
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DOI: 10.1002/cbic.202100670
Abstract: The thrombin binding aptamer (TBA) is a 15‐mer DNA oligonucleotide (5′‐GGT TGG TGT GGT TGG‐3′), that can form a stable intramolecular antiparallel chair‐like G‐quadruplex structure. This aptamer shows anticoagulant properties by interacting with one of… read more here.
Keywords: thrombin binding; stability; anticoagulant activity; binding aptamer ... See more keywords
Anticoagulant activity of apixaban can be estimated by multiple regression analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.12435
Abstract: Information on apixaban anticoagulant activity is required to prevent major bleeding or thrombosis during its use. read more here.
Keywords: estimated multiple; apixaban estimated; activity apixaban; anticoagulant activity ... See more keywords
Ruthenium chloride inhibits the anticoagulant activity of the phospholipase A2-dependent neurotoxin of Mojave rattlesnake Type A venom
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02479-3
Abstract: A unique nexus exists between coagulation and neurotoxicity that permits the assessment of the activity of destructive presynaptic phospholipase A2 (PLA2) enzymatic activity. This connection is that these enzymes can catalyze critical plasma phospholipids required… read more here.
Keywords: ruthenium; mojave rattlesnake; venom; anticoagulant activity ... See more keywords
Synthesis of N-succinyl- and N-glutaryl-chitosan derivatives and their antioxidant, antiplatelet, and anticoagulant activity.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.02.097
Abstract: The effects of temperature, reactant ratio, pH, and reaction time were studied on the polymers formed by the reactions of succinic and glutaric anhydrides with chitosan under both homogeneous and heterogeneous conditions. As a result,… read more here.
Keywords: glutaryl chitosan; succinyl glutaryl; anticoagulant activity; synthesis succinyl ... See more keywords
Characterization and anticoagulant activity of a fucosylated chondroitin sulfate with unusually procoagulant effect from sea cucumber.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.06.128
Abstract: The fucosylated chondroitin sulfate (FuCS) was isolated from the sea cucumber Holothuria polii body wall and then purified by anion exchange chromatography and the structure was characterized by FT-IR and NMR spectroscopy. Anticoagulant activity was… read more here.
Keywords: sulfate; fucosylated chondroitin; anticoagulant activity; chondroitin sulfate ... See more keywords
Effects of carboxyl group on the anticoagulant activity of oxidized carrageenans.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.03.057
Abstract: In this paper, carrageenans having distinct sulfation patterns (κ-, ι-, ι/ν-, θ- and λ-carrageenans), were fully or partially oxidized at C-6 of the β-d-Galp units using 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and trichloroisocyanuric acid (TCCA) in bicarbonate buffer.… read more here.
Keywords: sulfate; anticoagulant activity; carboxyl group; group anticoagulant ... See more keywords
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples
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DOI: 10.1016/j.chembiol.2022.01.009
Abstract: Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging because they lack an active site. To address this, we isolate an RNA aptamer termed T18.3 that… read more here.
Keywords: anticoagulant aptamer; aptamer targets; generation anticoagulant; anticoagulant activity ... See more keywords
Studies on European eel skin sulfated glycosaminoglycans: Recovery, structural characterization and anticoagulant activity.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.125
Abstract: Abstract The goal of the present work was the extraction and structural characterization of novel sulfated glycosaminoglycans from European eel skin. The recovered glycosaminoglycans were physicochemically characterized and the uronic acid and sulfate contents were… read more here.
Keywords: anticoagulant activity; european eel; structural characterization; activity ... See more keywords
Structure and anticoagulant activity of a sulfated fucan from the sea cucumber Acaudina leucoprocta.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.080
Abstract: A sulfated fucan was extracted, purified, and characterized from Acaudina leucoprocta (a low value sea cucumber) to better understand and utilize this species. The structure of the sulfated fucan was elucidated using chemical and modern… read more here.
Keywords: sulfated fucan; acaudina leucoprocta; anticoagulant activity; activity ... See more keywords
Structure characterization and anticoagulant activity of a novel polysaccharide from Leonurus artemisia (Laur.) S. Y. Hu F
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DOI: 10.1039/c9ra10853j
Abstract: An acidic polysaccharide, named LAP-1, was extracted and isolated from Leonurus artemisia (Laur.), and was further purified with ion exchange chromatography and gel chromatography. The extraction conditions of the crude polysaccharides were optimized by single-factor… read more here.
Keywords: leonurus artemisia; artemisia laur; anticoagulant activity; structure ... See more keywords