A rationale for tRNA modification circuits in the anticodon loop.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.067736.118
Abstract: The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function. While most modifications are introduced to tRNA independently, several sets of modifications are found to be interconnected such that the presence of… read more here.
Keywords: rationale trna; anticodon loop; modification circuits; circuits acl ... See more keywords
Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway
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DOI: 10.1371/journal.pgen.1007288
Abstract: Modification defects in the tRNA anticodon loop often impair yeast growth and cause human disease. In the budding yeast Saccharomyces cerevisiae and the phylogenetically distant fission yeast Schizosaccharomyces pombe, trm7Δ mutants grow poorly due to… read more here.
Keywords: gaac activation; trnaphe; anticodon loop; trm7 mutants ... See more keywords