Anticryptococcal activity and mechanistic studies of short amphipathic peptides
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200576
Abstract: Cryptococcus neoformans, an opportunistic fungal pathogen, causes cryptococcosis in immunocompromised persons. A series of modified L‐histidines‐containing peptides are synthesized that exhibit promising activity against C. neoformans. Analog 11d [L‐His(2‐adamantyl)‐L‐Trp‐L‐His(2‐phenyl)‐OMe] produced potency with an IC50 of… read more here.
Keywords: short amphipathic; studies short; activity mechanistic; anticryptococcal activity ... See more keywords
Anticryptococcal activity of hexane extract from Spondias tuberosa Arruda and associated cellular events.
Sign Up to like & getrecommendations! Published in 2020 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2020.100965
Abstract: Cryptococcosis is an opportunistic systemic mycosis whose treatment is limited to three drugs. In this work, we evaluated the antifungal activity of a hexane extract (HE) from Spondias tuberosa leaves against Cryptococcus neoformans and Cryptococcus… read more here.
Keywords: spondias tuberosa; activity hexane; hexane extract; anticryptococcal activity ... See more keywords
Ring-Modified Histidine-Containing Cationic Short Peptides Exhibit Anticryptococcal Activity by Cellular Disruption
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010087
Abstract: Delineation of clinical complications secondary to fungal infections, such as cryptococcal meningitis, and the concurrent emergence of multidrug resistance in large population subsets necessitates the need for the development of new classes of antifungals. Herein,… read more here.
Keywords: modified histidine; histidine containing; anticryptococcal activity; microscopy ... See more keywords