Depression and antidepressant action—from molecules to networks
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03042-6
Abstract: Once in a while, we all experience feelings of hopelessness, sadness, lack of self-esteem, lack of motivation and drive, and difficulties to focus and concentrate. In far too many individuals, these physiological responses to environmental,… read more here.
Keywords: depression; molecules networks; depression antidepressant; antidepressant action ... See more keywords
Convergent Mechanisms Underlying Rapid Antidepressant Action
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DOI: 10.1007/s40263-018-0492-x
Abstract: Traditional pharmacological treatments for depression have a delayed therapeutic onset, ranging from several weeks to months, and there is a high percentage of individuals who never respond to treatment. In contrast, ketamine produces rapid-onset antidepressant,… read more here.
Keywords: underlying rapid; antidepressant action; convergent mechanisms; mechanisms underlying ... See more keywords
Adult hippocampal neurogenesis: Is it the alpha and omega of antidepressant action?
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DOI: 10.1016/j.bcp.2017.08.005
Abstract: ABSTRACT It is now well established that all clinically available antidepressants share a common aptitude: they increase the production of adult‐generated neurons in the dentate gyrus of the hippocampus. This was first observed in animal… read more here.
Keywords: adult; neurogenesis; hippocampal neurogenesis; action adult ... See more keywords
Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up‐regulating hippocampal PACAP signalling
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15847
Abstract: Current mainstream antidepressants have limited efficacy with a delayed onset of action. Yueju, a herbal medicine, has a rapid antidepressant action. Identification of the active ingredients in Yueju and the mechanism/s involved was carried out. read more here.
Keywords: effects two; antidepressant action; synergistic effects; action ... See more keywords