Lack of dopamine D1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model
Sign Up to like & getrecommendations! Published in 2019 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-019-01012-1
Abstract: It is reported that dopamine D 1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of ( R,S )-ketamine. However, its role in the antidepressant actions of ( R )-ketamine,… read more here.
Keywords: social defeat; antidepressant actions; dopamine receptors; defeat stress ... See more keywords
Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis
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DOI: 10.1016/j.neulet.2017.09.010
Abstract: The genus Passiflora is popularly used to treat anxiety. Recent studies showed antidepressant-like effects of two varieties of P. edulis (edulis and flavicarpa) in mice. However, the mechanisms of antidepressant actions are still unknown. Here,… read more here.
Keywords: neurotransmission mediating; antidepressant actions; like effects; acoet buoh ... See more keywords
BDNF Release and Signaling are Required for the Antidepressant Actions of GLYX-13
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DOI: 10.1038/mp.2017.220
Abstract: Conventional antidepressant medications, which act on monoaminergic systems, display significant limitations, including a time lag of weeks to months and low rates of therapeutic efficacy. GLYX-13 is a novel glutamatergic compound that acts as an… read more here.
Keywords: signaling required; antidepressant actions; release; actions glyx ... See more keywords
Cell-type specific modulation of NMDA receptors triggers antidepressant actions
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DOI: 10.1038/s41380-020-0796-3
Abstract: Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human studies. However, how this bidirectional modulation of NMDARs causes similar antidepressant effects… read more here.
Keywords: nmdar; type specific; cell type; antidepressant actions ... See more keywords
Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
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DOI: 10.1038/s41380-021-01121-1
Abstract: The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has been a crucial breakthrough in mood disorder research. (R,S)-ketamine is a racemic mixture of equal amounts of (R)-ketamine (arketamine) and… read more here.
Keywords: ketamine; antidepressant actions; mechanisms underlying; underlying antidepressant ... See more keywords
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
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DOI: 10.1038/s41386-018-0084-y
Abstract: Abstract(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine (HNK), a metabolite of (R)-ketamine, has been reported to be essential for its antidepressant effects, recent evidence suggests… read more here.
Keywords: ketamine; antidepressant actions; essential antidepressant; hnk ... See more keywords
(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14683
Abstract: (R)‐Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While (R)‐ketamine has lower potency than (R,S)‐ketamine to inhibit NMDA receptors in vitro, the extent to which (R)‐ketamine shares the NMDA receptor‐mediated adverse effects of… read more here.
Keywords: ketamine; antidepressant actions; exerts antidepressant; ketamine exerts ... See more keywords