Exploring N-heterocyclic linked novel hybrid chalcone derivatives: synthesis, characterization, evaluation of antidepressant activity, toxicity assessment, molecular docking, DFT and ADME study
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra01929j
Abstract: In the search for novel antidepressant agents, twelve novel nitrogen-containing heterocycle-linked chalcone derivatives have been synthesized and comprehensively characterized using FT-IR, 1H NMR, 13C NMR, and Mass spectral methods. The synthetic strategy involves the preparation… read more here.
Keywords: molecular docking; chalcone; chalcone derivatives; antidepressant activity ... See more keywords
Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2021.67.1.1
Abstract: The antidepressant activity of Spathodea campanulata flowers was evaluated in mice and in silico. When tested at doses of 200 and 400 mg/kg, the methanol extract of S. campanulata (MESC) showed dose-dependent antidepressant activity in… read more here.
Keywords: type monoamine; activity spathodea; campanulata; activity ... See more keywords
Antidepressant activity of ciprofloxacin and levofloxacin by using tail suspension test in Swiss albino mice on chronic administration
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Parallel Programming"
DOI: 10.18231/2393-9087.2018.0026
Abstract: Introduction: Depression is evidenced by decreased mood and reduced activity that can affect person's thoughts, behavior, feelings, and also sense of well-being in the society. Use of long term antidepressant agent pose a significant adverse… read more here.
Keywords: antidepressant activity; ciprofloxacin levofloxacin; activity; test ... See more keywords
Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.65.251
Abstract: Collagen is the most abundant protein in animals. Collagen hydrolysate has been found to have multiple functions in the skin, bones, joints, muscles, and blood vessels. Recently, it has been reported that the low molecular… read more here.
Keywords: collagen hydrolysate; antidepressant activity; activity; gdch ... See more keywords
Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00643
Abstract: Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE… read more here.
Keywords: antidepressant activity; spadin analogs; trek; stability ... See more keywords
A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1387158
Abstract: One of the most important developments in psychopharmacology in the past decade has been the emergence of novel treatments for mood disorders, such as psilocybin for treatment-resistant depression. Psilocybin is most commonly found in different… read more here.
Keywords: antidepressant activity; fungus extracts; depression; mushroom fungus ... See more keywords
Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030623
Abstract: Major Depression Disease is a common mental illness that affects more than 322 million people worldwide and it is one of the leading causes of mental and physical disability. The etiology of depression is a… read more here.
Keywords: depression; antidepressant activity; medicinal mushrooms; discovering potential ... See more keywords
Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082149
Abstract: It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates depression symptoms. New evidence indicates that SSRIs may… read more here.
Keywords: selective serotonin; antidepressant activity; serotonin reuptake; acetylcholine receptors ... See more keywords
In vitro antioxidant and in vivo antidepressant activity of green synthesized azomethine derivatives of cinnamaldehyde
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_293_16
Abstract: OBJECTIVES: In this study, three (CS-1 to CS-3) azomethine derivatives of cinnamaldehyde were green synthesized, characterized, and their antioxidant and antidepressant activities were explored. MATERIALS AND METHODS: The antioxidant effect of these compounds was initially… read more here.
Keywords: antidepressant activity; green synthesized; vivo; azomethine derivatives ... See more keywords
Synthesis and Antidepressant activity of 3, 4-dihydropyrimidin-2(1H)-ones
Sign Up to like & getrecommendations! Published in 2019 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2019.00962.4
Abstract: Derivatives of 3, 4- dihydropyrimidin-2(1H)-one and2, 5dioxo,4-aryl octahydroquinazolines were synthesized by microwave irradiation. The synthesized derivatives were characterized for physicochemical parameters and the spectroscopic studies. Compounds were screened for its antidepressant activity by using Tail… read more here.
Keywords: synthesis antidepressant; test; activity; dihydropyrimidin ones ... See more keywords