Lurasidone-β-cyclodextrin complexes: Physicochemical characterization and comparison of their antidepressant, antipsychotic activities against that of self microemulsifying formulation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.12.042
Abstract: Abstract Lurasidone hydrochloride (LHD) is an atypical antipsychotic drug has poor aqueous solubility and low bioavailability (9–19%). This study describes effect of different methods of complex formation with β-cyclodextrin (BCD) on enhancement of dissolution and… read more here.
Keywords: bcd; self microemulsifying; cyclodextrin; antidepressant antipsychotic ... See more keywords
Antidepressant and antipsychotic poisoning
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DOI: 10.1016/j.mpmed.2019.12.012
Abstract: Abstract Tricyclic antidepressants, citalopram, venlafaxine and monoamine oxidase inhibitors are the most toxic antidepressants in overdose. Features include hypotension and arrhythmias that are best managed by aggressive correction of metabolic acidosis with sodium bicarbonate. Antipsychotic… read more here.
Keywords: medicine; antidepressant antipsychotic; antipsychotic poisoning;
Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies
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DOI: 10.3390/ijms24119482
Abstract: Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for… read more here.
Keywords: potential molecular; antidepressant antipsychotic; molecular targets; antipsychotic pharmacotherapies ... See more keywords