NMDA receptor antagonists traxoprodil and lanicemine improve hippocampal-prefrontal coupling and reward-related networks in rats
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05310-3
Abstract: RationaleThe N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine is known to have not only a rapid antidepressant effect but also dissociative side effects. Traxoprodil and lanicemine, also NMDA antagonists, are candidate antidepressant drugs with fewer side effects.ObjectivesIn… read more here.
Keywords: ketamine; connectivity; antidepressant effect; effect ... See more keywords
Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108679
Abstract: BACKGROUND AND PURPOSE Although useful as a rapid-acting antidepressant drug, ketamine is known to induce psychotomimetic effects, which may interfere with its therapeutic use. Cannabidiol (CBD) is a non-psychostimulant compound from Cannabis sativa, which has… read more here.
Keywords: cbd; ketamine; effect; antidepressant effect ... See more keywords
Volume of hippocampal subregions and clinical improvement following electroconvulsive therapy in patients with depression
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110048
Abstract: It is thought that the hippocampal neurogenesis is an important mediator of the antidepressant effect of electroconvulsive therapy (ECT). However, most previous studies failed to demonstrate the relationship between the increase in the hippocampal volume… read more here.
Keywords: depression; volume; hippocampal subregions; clinical improvement ... See more keywords
Antidepressant Effect of Ketamine on Inflammation-Mediated Cytokine Dysregulation in Adults with Treatment-Resistant Depression: Rapid Systematic Review
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1061274
Abstract: Background Major depressive disorder (MDD) and treatment-resistant depression (TRD) represent a global source of societal and health burden. To advise proper management of inflammation-related depression among TRD patients, it is important to identify therapeutic clinical… read more here.
Keywords: trd patients; ketamine; depression; antidepressant effect ... See more keywords
Suggestive Evidence for an Antidepressant Effect of Metreleptin Treatment in Patients with Lipodystrophy
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DOI: 10.1159/000526357
Abstract: Introduction: Lipodystrophy (LD) syndromes are rare heterogeneous disorders characterized by reduction or absence of subcutaneous fat, low or nondetectable leptin concentrations in blood and impaired hunger/satiety regulation. Metreleptin treatment reverses metabolic complications and improves eating… read more here.
Keywords: treatment; antidepressant effect; depression; metreleptin treatment ... See more keywords
Antidepressant Effect and Recognition Memory Improvement of Two Novel Plant Extract Combinations - Antistress I and Anti-stress II on Rats Subjected to a Model of Mild Chronic Stress
Sign Up to like & getrecommendations! Published in 2018 at "Folia Medica"
DOI: 10.1515/folmed-2017-0073
Abstract: Abstract Background: Chronic stress is one of the main factors which lead to depression – a psychiatric disorder affecting millions of people and predicted to be the second ranked cause of premature death in 2020.… read more here.
Keywords: antidepressant effect; recognition memory; stress; memory ... See more keywords
Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.826055
Abstract: Depressive disorder is defined as a psychiatric disease characterized by the core symptoms of anhedonia and learned helplessness. Currently, the treatment of depression still calls for medications with high effectiveness, rapid action, and few side… read more here.
Keywords: amylin; antidepressant effect; salmon calcitonin; amylin receptors ... See more keywords
Integration of Non-Targeted Metabolomics and Targeted Quantitative Analysis to Elucidate the Synergistic Antidepressant Effect of Bupleurum Chinense DC-Paeonia Lactiflora Pall Herb Pair by Regulating Purine Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.900459
Abstract: Graphical Abstract Bupleurum chinense DC (Chaihu)-Paeonia lactiflora Pall (Baishao) is among the most accepted herb pairs in many classic antidepressant prescriptions. Our previous study has shown that the Chaihu–Baishao herb pair (CBHP) had a better… read more here.
Keywords: effect; purine metabolism; antidepressant effect; analysis ... See more keywords
Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.1076459
Abstract: Introduction Current treatment options for major depressive disorder (MDD) have limited efficacy and are associated with adverse effects. Recent studies investigating the antidepressant effect of serotonergic psychedelics—also known as classic psychedelics—have promising preliminary results with… read more here.
Keywords: action serotonergic; action; antidepressant effect; serotonergic psychedelics ... See more keywords
Antidepressant effect of methanol stem bark extract of Adansonia digitata: involvement of monoaminergic, nitric oxide and cholinergic pathways
Sign Up to like & getrecommendations! Published in 2020 at "Journal of HerbMed Pharmacology"
DOI: 10.34172/jhp.2021.08
Abstract: Introduction: Hausa people of north-western Nigeria were reported to utilize the plant Adansonia digitata for the management of depressive illnesses in an ethnobotanical survey. Thus, this study aimed to establish the mechanism(s) via which methanol… read more here.
Keywords: stem bark; antidepressant effect; nitric oxide; bark extract ... See more keywords