Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide
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DOI: 10.1002/ddr.21578
Abstract: Salvia tiliifolia is used in folk medicine as a relaxant agent and for the treatment of diarrhea and neurodegenerative diseases. Tilifodiolide (TFD) is a diterpene obtained from this plant. The purpose of this work was… read more here.
Keywords: neuropharmacological actions; tfd; antidiarrheal; antidiarrheal vasorelaxant ... See more keywords
Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate‐activated protein kinase—UNC‐51‐like kinase 1 pathway
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DOI: 10.1002/iub.1731
Abstract: Positive regulation of autophagy by Euryale ferox Salisb (ES) leads to antidepressant effects. This study focused on the potential antidepressant mechanisms induced by the petroleum ether fraction of ES (ES‐PE) in the chronically unpredictable mild… read more here.
Keywords: kinase; activated protein; protein kinase; euryale ferox ... See more keywords
Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission
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DOI: 10.1002/ptr.6812
Abstract: Several studies reported the relative antidepressant effects of Fructus Aurantii (FRA) with repeated treatment, the rapid antidepressant effects of FRA and the underlying mechanisms remained unclear. We, therefore, examined the rapid antidepressant actions of FRA… read more here.
Keywords: camp response; fructus aurantii; element binding; rapid antidepressant ... See more keywords
Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model
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DOI: 10.1016/j.bbr.2017.06.010
Abstract: Resolvin D1 (RvD1) and D2 (RvD2) are lipid mediators that are derived from docosahexaenoic acid. We recently demonstrated that intracerebroventricular (i.c.v.) infusions of RvD1 or RvD2 attenuate lipopolysaccharide-induced depression-like behaviors via mammalian target of rapamycin… read more here.
Keywords: rapid sustained; unpredictable stress; chronic unpredictable; rvd1 rvd2 ... See more keywords
Mechanistic Target of Rapamycin–Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.05.016
Abstract: BACKGROUND The role of the mechanistic target of rapamycin (mTOR) signaling in the antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal-regulated kinase (ERK) is a key signaling molecule in prominent pathways… read more here.
Keywords: effects ketamine; model; ketamine ketamine; mtor ... See more keywords
New Insight Into the Mechanisms of Fast-Acting Antidepressants: What We Learn From Scopolamine
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.001
Abstract: For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large… read more here.
Keywords: acting antidepressants; new insight; fast acting; rapid antidepressant ... See more keywords
Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.12.006
Abstract: The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in treating severe depression; 2) spurred a wave of basic, translation, and… read more here.
Keywords: rapid acting; pathology; effects ketamine; neurobiology ... See more keywords
mGlu receptors as potential targets for novel antidepressants
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DOI: 10.1016/j.coph.2018.02.001
Abstract: HighlightsmGlu2/3 antagonists exert ketamine‐like antidepressant effects in rodent models.mGlu2/3 antagonists shared some of their mechanisms with ketamine.mGlu5 NAMs exert antidepressant effects in rodent models.The mechanisms of mGlu5 NAMs may differ from those of ketamine.Antidepressant potential… read more here.
Keywords: novel antidepressants; mglu receptors; potential targets; receptor ... See more keywords
P.2.032 ZL006 has antidepressant effects and attenuates changes in dendritic spines associated with astrocytic impairment in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.071
Abstract: The NMDA receptor (NMDA-R) remains a promising target for treating CNS disorders including depression. Directly targeting NMDA-R is however liable to produce unwanted adverse effects. Previous studies demonstrate that nitric oxide (NO) synthase inhibitors are… read more here.
Keywords: depression; mice; changes dendritic; zl006 ... See more keywords
Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model
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DOI: 10.1016/j.heliyon.2019.e01600
Abstract: Nicotine is the most common and highly addictive drug of abuse, associated with several life-threatening diseases and high mortality. Nicotine abuse is the concerted effort to feel reward and fight depression in depressed individuals. The… read more here.
Keywords: depression; chronic unpredictable; unpredictable mild; sonic hedgehog ... See more keywords
Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.111967
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Acrorus tatarinowii Schott has been widely used in the treatments of neuropsychiatric and digestive disorders in clinical practices of traditional Chinese medicine for thousands of years. Both clinical and preclinical studies demonstrated antidepressant… read more here.
Keywords: water extract; water; acid; activity ... See more keywords