TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.201
Abstract: Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB), have important roles in neural plasticity and are required for antidepressant efficacy. Studies examining the role of BDNF-TrkB signaling in depression… read more here.
Keywords: trkb signaling; trkb; antidepressant efficacy; dorsal raphe ... See more keywords
Venlafaxine stimulates PNN proteolysis and MMP‐9‐dependent enhancement of gamma power; relevance to antidepressant efficacy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14671
Abstract: Drugs that target monoaminergic transmission represent a first‐line treatment for major depression. Though a full understanding of the mechanisms that underlie antidepressant efficacy is lacking, evidence supports a role for enhanced excitatory transmission. This can… read more here.
Keywords: antidepressant efficacy; gamma power; mmp; power ... See more keywords
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Neural Plasticity"
DOI: 10.1155/2019/4651031
Abstract: An increasing number of studies show that selective serotonin reuptake inhibitors (SSRIs) exert their therapeutic action, at least in part, by amplifying the influence of the living environment on mood. As a consequence, when administered… read more here.
Keywords: fluoxetine metformin; treatment; expression; antidepressant efficacy ... See more keywords
Biomarkers for Antidepressant Efficacy of Electroconvulsive Therapy: An Exploratory Cerebrospinal Fluid Study
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychobiology"
DOI: 10.1159/000491401
Abstract: Background: No candidate biomarkers based on cerebrospinal fluid (CSF) have been identified as prognostic factors in patients with major depression treated with electroconvulsive therapy (ECT), yet. Method: Following different underlying hypotheses, we analysed baseline CSF… read more here.
Keywords: antidepressant efficacy; biomarkers antidepressant; electroconvulsive therapy; therapy ... See more keywords
Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881118812095
Abstract: Background: (R,S)-ketamine has gained attention for its rapid-acting antidepressant actions in patients with treatment-resistant depression. However, widespread use of ketamine is limited by its side effects, abuse potential, and poor oral bioavailability. The ketamine metabolite,… read more here.
Keywords: oral bioavailability; hydroxynorketamine; bioavailability; antidepressant efficacy ... See more keywords
A Role for Matrix Metalloproteases in Antidepressant Efficacy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00117
Abstract: Major depressive disorder is a debilitating condition that affects approximately 15% of the United States population. Though the neurophysiological mechanisms that underlie this disorder are not completely understood, both human and rodent studies suggest that… read more here.
Keywords: expressing interneurons; pyramidal cell; matrix; antidepressant efficacy ... See more keywords
Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2020.00151
Abstract: Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major ways to ease or treat MDD. However, the… read more here.
Keywords: depressive disorder; single nucleotide; major depressive; antidepressant efficacy ... See more keywords