Antidepressant‐like effect of flaxseed in rats exposed to chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1626
Abstract: Depression is a serious mental illness. However, a significant proportion of patients with depression fail to achieve remission with antidepressant therapies. This study was conducted to explore the antidepressant‐like effect of flaxseed oil and flour… read more here.
Keywords: unpredictable stress; chronic unpredictable; like effect; effect flaxseed ... See more keywords
Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23850
Abstract: Despite sigma‐1 receptor (Sig‐1R) is a promising therapeutic target in depression, little is known regarding the cellular mechanisms underlying its antidepressant responses. Here, we demonstrated that astrocyte can be a direct cellular target of Sig‐1R… read more here.
Keywords: like effect; activation; sigma receptor; sig ... See more keywords
Delta Opioid Receptors and Modulation of Mood and Emotion.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_42
Abstract: Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to… read more here.
Keywords: dor agonists; like effects; mood; delta opioid ... See more keywords
Evidence for the involvement of opioid system in the antidepressant-like effect of ascorbic acid
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1446-4
Abstract: Considering the involvement of the opioid system in major depressive disorder (MDD), mainly concerning refractory MDD, and the evidence that ascorbic acid may exert a beneficial effect for the treatment of this disorder, this study… read more here.
Keywords: opioid system; ascorbic acid; effect; acid ... See more keywords
Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4761-z
Abstract: RationaleMajor depressive disorder (MDD) is a highly prevalent illness that affects large populations across the world, and increasing evidence suggests that neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are closely related to depression. Dihydromyricetin… read more here.
Keywords: depression; like effect; effect; antidepressant like ... See more keywords
Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4940-6
Abstract: RationaleDepressed patients often present increased consumption of caffeine.ObjectivesWe aimed to investigate the effects of chronic treatment with caffeine (5 mg/kg, twice daily for 14 days) on the activity of single, ineffective doses of agomelatine (20 mg/kg) or mianserin… read more here.
Keywords: administration; caffeine; comt; day ... See more keywords
Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05372-3
Abstract: The association between depression and diabetes has been recognized for many years, but the nature of this relationship remains uncertain. This study investigated the antidepressant-like effect of (p-ClPhSe)2 on mice made diabetic by streptozotocin (STZ)… read more here.
Keywords: keap1 nrf2; pathway; mice; diabetic mice ... See more keywords
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05849-0
Abstract: Rationale The prevalence of depression is ever-increasing throughout the population. However, available treatments are ineffective in around one-third of patients and there is a need for more effective and safer drugs. Objectives The antidepressant-like and… read more here.
Keywords: agonists f15599; f15599 f13714; unpredictable chronic; like properties ... See more keywords
The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09681-2
Abstract: Although guanosine is an endogenous nucleoside that displays antidepressant-like properties in several animal models, the mechanism underlying its antidepressant-like effects is not well characterized. The present study aimed at investigating the involvement of ERK/GSK-3β and… read more here.
Keywords: like effect; gsk; effect guanosine; antidepressant like ... See more keywords
Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1143-4
Abstract: Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic… read more here.
Keywords: rapid sustained; like effects; sustained antidepressant; antidepressant like ... See more keywords
Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9715-z
Abstract: Biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders especially depression. Animal models are widely used to study antidepressant-like effect in rodents; however, it should be… read more here.
Keywords: like effect; clonidine induced; clonidine; endogenous neuroprotective ... See more keywords