Preclinical sex differences in depression and antidepressant response: Implications for clinical research
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23861
Abstract: Women suffer from depression and anxiety disorders more often than men, and as a result they receive antidepressants to a greater extent. Sex differences in antidepressant response in humans have been modestly studied, and results… read more here.
Keywords: depression; research; sex differences; sex ... See more keywords
Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review
Sign Up to like & getrecommendations! Published in 2019 at "Current Psychiatry Reports"
DOI: 10.1007/s11920-019-1072-6
Abstract: Poor treatment response is a hallmark of major depressive disorder. To tackle this problem, recent neuroimaging studies have sought to characterize antidepressant response in terms of pretreatment differences in intrinsic functional brain networks. Our aim… read more here.
Keywords: network; treatment response; response; antidepressant response ... See more keywords
Predicting antidepressant response using early changes in cognition: A systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.011
Abstract: Background: Despite the widespread use of antidepressants in clinical practice, the current trial‐and‐error approach to medication selection contributes to treatment failure and underscores the need to identify reliable predictors of antidepressant response. Since changes in… read more here.
Keywords: response; treatment; systematic review; antidepressant response ... See more keywords
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2016.05.005
Abstract: In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional connectivity patterns within large brain networks. Network dysfunction in association with altered… read more here.
Keywords: gamma aminobutyric; glutamate gamma; response; ketamine ... See more keywords
Predicting Antidepressant Response from Genes
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.2044
Abstract: Introduction Pharmacogenetics may inform an accurate prescribing of antidepressants by identifying the genetic background specifically responding to a certain drug. Despite decades of efforts though, pharmacogenetics appears to be still in its infancy. Aim A… read more here.
Keywords: predicting antidepressant; response genes; response; antidepressant response ... See more keywords
Frontocingulate cerebral blood flow and cerebrovascular reactivity associated with antidepressant response in late-life depression.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.03.027
Abstract: BACKGROUND Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical… read more here.
Keywords: depression; late life; pathology; cvr ... See more keywords
Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.172856
Abstract: Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews… read more here.
Keywords: long term; ketamine; response ketamine; antidepressant response ... See more keywords
Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.02.048
Abstract: AIMS We reviewed studies that reported speed of antidepressant response to electroconvulsive therapy (ECT) in both bipolar depression (BPD) and major depressive disorder (MDD). METHODS We identified English language reports allowing this comparison. RESULTS Ten… read more here.
Keywords: response electroconvulsive; response; disorder; antidepressant response ... See more keywords
Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity
Sign Up to like & getrecommendations! Published in 2017 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2017.02.019
Abstract: BACKGROUND A better understanding of factors underlying antidepressant non-response may improve the prediction of which patients will respond to what treatment. Major depressive disorder (MDD) is associated with alterations in fatty acid metabolism, (neuro)inflammation and… read more here.
Keywords: neuro inflammation; amygdala reactivity; response; antidepressant response ... See more keywords
Hippocampal subregions and networks linked with antidepressant response to electroconvulsive therapy
Sign Up to like & getrecommendations! Published in 2020 at "Molecular psychiatry"
DOI: 10.1038/s41380-020-0666-z
Abstract: Electroconvulsive therapy (ECT) has been repeatedly linked to hippocampal plasticity. However, it remains unclear what role hippocampal plasticity plays in the antidepressant response to ECT. This magnetic resonance imaging (MRI) study tracks changes in separate… read more here.
Keywords: electroconvulsive therapy; hippocampal subregions; hippocampus; antidepressant response ... See more keywords
Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychopharmacology"
DOI: 10.1177/02698811211044684
Abstract: BACKGROUND Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation of early response… read more here.
Keywords: placebo; accuracy recognising; treatment; antidepressant response ... See more keywords