Mesocortical BDNF signaling mediates antidepressive-like effects of lithium
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DOI: 10.1038/s41386-020-0713-0
Abstract: Lithium has been used to treat major depressive disorder, yet the neural circuit mechanisms underlying this therapeutic effect remain unknown. Here, we demonstrated that the ventral tegmental area (VTA) dopamine (DA) neurons that project to… read more here.
Keywords: antidepressive like; nac projecting; projecting vta; like effects ... See more keywords
Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071572
Abstract: Sigma-1 receptor (Sig1R) has been proposed as a therapeutic target for neurological, neurodegenerative, and psychiatric disorders, including depression and anxiety. Identifying metabolites that are affected by Sig1R absence and cross-referencing them with specific mood-related behaviors… read more here.
Keywords: sigma receptor; knockout mice; antidepressive like;