Medicinal Chemistry, SAR, and Molecular Insights Into 2,4‐Thiazolidinediones as Antidiabetic Agents (2020–2025)
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DOI: 10.1002/ardp.70102
Abstract: The thiazolidinedione (TZD) scaffold has long been recognized for its pharmacological versatility, particularly in the treatment of metabolic and inflammatory disorders. Among its derivatives, 2,4‐thiazolidinediones (2,4‐TZDs) have emerged as a prominent class of antidiabetic agents… read more here.
Keywords: chemistry; 2025 medicinal; chemistry sar; antidiabetic agents ... See more keywords
Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients
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DOI: 10.1002/jcp.27278
Abstract: Many vascular complications are related to exposure of tissues to elevated levels of glucose, a condition that promotes oxidative stress. The primary goal of antidiabetic medication is for normalization of blood glucose. However, antidiabetic medications… read more here.
Keywords: agents possible; possible protective; potential antidiabetic; vascular complications ... See more keywords
Insight in the safety profile of antidiabetic agents glucagon‐like peptide‐1 agonists and dipeptidyl peptidase‐4 inhibitors in daily practice from the patient perspective
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DOI: 10.1002/pds.5077
Abstract: The primary aim of this study was to gain insight in the safety profile of the new antidiabetic agents glucagon‐like peptide‐1 (GLP‐1) agonists and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in daily practice. The secondary aim was… read more here.
Keywords: safety profile; safety; insight safety; practice ... See more keywords
Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents.
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DOI: 10.1016/j.bioorg.2019.103527
Abstract: Diabetes mellitus (DM) is a serious chronic metabolic disorder which occurs due to dysfunction of insulin and therapeutic approaches are poor. It is an under estimation that 387 million people currently suffering globally with diabetic… read more here.
Keywords: design synthesis; synthesis docking; biological evaluation; evaluation chalcones ... See more keywords
Oral Antidiabetic Agents and Cardiovascular Outcomes.
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DOI: 10.1016/j.cpcardiol.2017.07.003
Abstract: Cardiovascular disease is the leading cause of morbidity and mortality among patients with type 2 diabetes; however, a direct protective effect of tight glycemic control remains unproven. In fact, until 2008, when concerns related to… read more here.
Keywords: antidiabetic agents; agents cardiovascular; oral antidiabetic; cardiovascular outcomes ... See more keywords
Antidiabetic drugs and stroke risk. Current evidence.
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DOI: 10.1016/j.ejim.2017.09.019
Abstract: Cardiovascular disease (CVD) is the major cause of morbidity and mortality for individuals with type 2 diabetes (T2D). In particular, the risk for stroke is twice that of patients without diabetes, and diabetes may be… read more here.
Keywords: antidiabetic drugs; risk; stroke risk; evidence ... See more keywords
Thiazolidinediones and PPAR orchestra as antidiabetic agents: From past to present.
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DOI: 10.1016/j.ejmech.2016.12.020
Abstract: Thiazolidinediones a class of drug, that provided a major breakthrough in the management of type 2 diabetes since 1990. Following the discovery of PPARs, TZDs were the first class to be reported as PPARγ modulators.… read more here.
Keywords: thiazolidinediones ppar; agents past; linker; ppar orchestra ... See more keywords
Synthesis and In vitro Biological Evaluation of Quinolone-Based Hydrazones as Potential Antidiabetic Agents Targeting Key Metabolic Enzymes
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DOI: 10.1021/acsomega.5c04663
Abstract: A series of novel structures featuring quinolone-based hydrazones (5a–5q) were synthesized, characterized, and screened for their potential inhibition of key enzymes involved in carbohydrate metabolism, namely human pancreatic α-amylase (HPA) and human lysosomal acid α-glucosidase,… read more here.
Keywords: quinolone based; antidiabetic agents; aldose reductase; based hydrazones ... See more keywords
An investigation of physicians' prescribing behaviors related to antidiabetic agents for Type 2 diabetes mellitus patients and associated factors in Taiwan
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DOI: 10.1080/03007995.2022.2105539
Abstract: Abstract Objectives This study aimed to examine the factors that may influence physicians’ choice of antidiabetic agents. In addition, we investigated physicians’ decision-making process and treatment of T2DM patients with chronic kidney disease (CKD). Finally,… read more here.
Keywords: prescribing behaviors; investigation physicians; behaviors related; physicians prescribing ... See more keywords
The potential effects of clinical antidiabetic agents on SARS‐CoV‐2
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DOI: 10.1111/1753-0407.13135
Abstract: Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), is currently posing significant threats to public health worldwide. It is notable that a substantial proportion of patients with sever COVID‐19 have coexisting… read more here.
Keywords: clinical antidiabetic; effects clinical; agents sars; potential effects ... See more keywords
Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta‐analysis
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DOI: 10.1111/dom.13373
Abstract: This study (registered with PROSPERO, CRD42018085967) compares the efficacy (i.e. pro‐cognitive effects) and acceptability of antidiabetic agents for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Cochrane Library (CENTRAL), PubMed/MEDLINE, EMBASE and PsycINFO were searched… read more here.
Keywords: acceptability; alzheimer disease; agents alzheimer; acceptability antidiabetic ... See more keywords