Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine‐rich glioma‐inactivated protein 1
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DOI: 10.1002/epi4.12226
Abstract: To characterize seizure semiology and the utility of antiepileptic drug (AED) therapy in leucine‐rich glioma inactivated‐1 ( LGI1‐Ab) autoimmune epilepsy (AE). read more here.
Keywords: leucine rich; autoimmune epilepsy; glioma inactivated; rich glioma ... See more keywords
Management of antiepileptic drug–induced nutrition-related adverse effects
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DOI: 10.1007/s10072-020-04573-5
Abstract: Although antiepileptic drugs (AEDs) are mainstay of the treatment of epilepsy, they are associated with significant adverse effects. The present study reviews the adverse effects of AEDs on some of the nutrition-related issues, including bone… read more here.
Keywords: drug induced; nutrition; adverse effects; nutrition related ... See more keywords
Preoperative antiepileptic drug prophylaxis for early postoperative seizures in supratentorial meningioma: a single-center experience
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DOI: 10.1007/s11060-022-04009-4
Abstract: Perioperative antiepileptic drug (AED) prophylaxis for early postoperative seizures (EPSs) in patients with supratentorial meningiomas without preoperative seizures is controversial. This paper discusses the incidence, risk factors, control rate and AED withdrawal indications of EPS… read more here.
Keywords: prophylaxis early; meningioma; preoperative seizures; without preoperative ... See more keywords
The First‐Time Seizure Emergency Department Electroencephalogram Study
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DOI: 10.1016/j.annemergmed.2016.08.004
Abstract: Study objective Seizures account for 1.2% of all emergency department (ED) visits, with 24% of those representing first‐time seizures. Our primary goal is to determine whether obtaining an electroencephalogram (EEG) in the ED after a… read more here.
Keywords: study; first time; seizure; antiepileptic drug ... See more keywords
Patterns of antiepileptic drug use among elderly patients with epilepsy: 2004-2015
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DOI: 10.1016/j.eplepsyres.2020.106297
Abstract: OBJECTIVE Certain antiepileptic drugs (AEDs) may be more suitable for elderly patients with epilepsy (EWE) relative to others. However, little is known regarding which antiepileptic drugs (AEDs) are being used to treat EWE in the… read more here.
Keywords: use; patterns antiepileptic; 2004 2015; elderly patients ... See more keywords
A review of the drug−drug interactions of the antiepileptic drug brivaracetam
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DOI: 10.1016/j.eplepsyres.2020.106327
Abstract: Brivaracetam is an antiepileptic drug (AED) indicated for the treatment of focal seizures, with improved safety and tolerability vs first-generation AEDs. Brivaracetam binds with high affinity to synaptic vesicle protein 2A in the brain, which… read more here.
Keywords: brivaracetam; drug interactions; drug; review drug ... See more keywords
The antiepileptic drug levetiracetam promotes neuroblast differentiation and expression of superoxide dismutase in the mouse hippocampal dentate gyrus via PI3K/Akt signalling
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DOI: 10.1016/j.neulet.2017.10.010
Abstract: Levetiracetam (LEV), a second-generation antiepileptic drug, is commonly prescribed to treat certain types of seizures. Few studies have investigated the effects of LEV on hippocampal neurogenesis and its related mechanisms. In the present study, we… read more here.
Keywords: pi3k; neuroblast differentiation; differentiation; mouse hippocampal ... See more keywords
Synthesis of benzoin under supramolecular catalysis involving cyclodextrins in water: application for the preparation of the antiepileptic drug phenytoin
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DOI: 10.1039/d1ra09062c
Abstract: Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-β-CD can be recycled several times with little loss of activity… read more here.
Keywords: drug phenytoin; water; synthesis; benzoin ... See more keywords
A real-world pharmacovigilance study of severe cutaneous adverse reactions associated with antiepileptic drug combination therapy: data mining of FDA adverse event reporting system.
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DOI: 10.1080/14740338.2023.2147506
Abstract: BACKGROUND Cutaneous toxicity is one of the most noteworthy adverse reactions of antiepileptic drugs. The aim of this study was to evaluate the association between antiepileptic drug combination regimens and severe cutaneous adverse reactions (SCAR).… read more here.
Keywords: ror; adverse reactions; combination; reporting ... See more keywords
Determining when to stop antiepileptic drug treatment
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DOI: 10.1097/wco.0000000000000530
Abstract: Purpose of review As the number of patients diagnosed with epilepsy continues to rise and the pharmacological and device-based treatment options for epilepsy increase, determining when to stop antiepileptic drug (AED) treatment continues to be… read more here.
Keywords: determining stop; treatment; stop antiepileptic; antiepileptic drug ... See more keywords
Extrapolating evidence of antiepileptic drug efficacy in adults to children ≥2 years of age with focal seizures: The case for disease similarity
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DOI: 10.1111/epi.13859
Abstract: Expediting pediatric access to new antiseizure drugs is particularly compelling, because epileptic seizures are the most common serious neurological symptom in children. Analysis of antiepileptic drug (AED) efficacy outcomes of randomized controlled trials, conducted during… read more here.
Keywords: age; efficacy; drug; focal seizures ... See more keywords