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Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.4699
Abstract: Importance Recent studies have highlighted an association between epilepsy and Parkinson disease (PD). The role of antiepileptic drugs (AEDs) has not been explored. Objective To investigate the association between AEDs and incident PD. Design, Setting,…
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Keywords:
diagnosis;
prescription;
parkinson disease;
antiepileptic drugs ... See more keywords
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Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50829
Abstract: An epilepsy mouse model for Tuberous Sclerosis Complex (TSC) was developed and validated to investigate the mechanisms underlying epileptogenesis. Furthermore, the possible antiepileptogenic properties of commonly used antiepileptic drugs (AEDs) and new compounds were assessed.
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Keywords:
antiepileptic drugs;
mouse model;
epilepsy mouse;
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Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25641
Abstract: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of TDM of newer generation…
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Keywords:
antiepileptic drugs;
therapeutic drug;
drug monitoring;
monitoring newer ... See more keywords
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Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21889
Abstract: Serum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL. The present article focuses on the in vitro inhibition role of…
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Keywords:
serum paraoxonase;
impacts human;
human serum;
drugs impacts ... See more keywords
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Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200246
Abstract: This paper aims to establish a simple and easy HPLC system coupled with UV detector suitable for simultaneous determination of 24 antiepileptic drugs in human plasma. Optimized chromatographic separation was performed on a ZORBAX Eclipse…
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Keywords:
easy hplc;
antiepileptic drugs;
hplc system;
suitable determination ... See more keywords
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Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-10153-6
Abstract: Objective The clinical spectrum of tics induced by antiepileptic drugs (AED), a form of ‘secondary Tourettism’, is largely unknown. Examining the literature aimed to help clinicians identify, understand and manage these cases. Understanding the mechanism…
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Keywords:
induced antiepileptic;
pragmatic review;
drugs pragmatic;
review ... See more keywords
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Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00021-1
Abstract: Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs…
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Keywords:
natural analog;
effect;
antiepileptic drugs;
activity ... See more keywords
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Published in 2019 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-019-01231-2
Abstract: Drug counseling is important in women with epilepsy since data about the effects of maternal antiepileptics on the developing fetus are limited. Although pregnant patients on the most teratogenic drugs are treated in accordance to…
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Keywords:
cross sectional;
valproate;
pregnant women;
drug ... See more keywords
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Published in 2020 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-020-01292-8
Abstract: Fatigue is a frequently reported symptom in patients with epilepsy (PWE) while the pathophysiology, causes and effects on the disease are not yet fully understood. Fatigue may occur as a side effect of antiepileptic drugs…
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Keywords:
inter ictal;
ictal fatigue;
fatigue;
antiepileptic drugs ... See more keywords
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Published in 2017 at "CNS Drugs"
DOI: 10.1007/s40263-016-0406-8
Abstract: This paper discusses the issues surrounding the tolerability and safety of the commonly used antiepileptic drugs (AEDs) in adolescents and adults. The content includes dose-related adverse effects, idiosyncratic reactions, behavioural and psychiatric comorbidities, chronic problems,…
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Keywords:
tolerability safety;
commonly used;
safety commonly;
adolescents adults ... See more keywords
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Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0509-5
Abstract: Status epilepticus (SE) is one of the most frequent neurological emergencies. Despite this, understanding of its pathophysiology and evidence regarding its management is limited. Rapid, effective, and well-tolerated treatment to achieve seizure cessation is advocated…
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Keywords:
newer antiepileptic;
evidence;
status epilepticus;
antiepileptic drugs ... See more keywords