Menthol exerts TRPM8-independent antiepileptic effects in prefrontal cortex pyramidal neurons
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DOI: 10.1016/j.brainres.2022.147847
Abstract: Menthol is a natural compound that evokes cold sensations by activating TRPM8 channels in peripheral sensory receptors. Little is known about the effects of this compound on brain neurons. It has been shown previously that… read more here.
Keywords: antiepileptic effects; ictal events; menthol; neurons menthol ... See more keywords
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model
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DOI: 10.1111/bph.14202
Abstract: A non‐psychoactive phytocannabinoid, cannabidiol (CBD), shows promising results as an effective potential antiepileptic drug in some forms of refractory epilepsy. To elucidate the mechanisms by which CBD exerts its anti‐seizure effects, we investigated its effects… read more here.
Keywords: restoring hippocampal; exerts antiepileptic; effects restoring; antiepileptic effects ... See more keywords
Zebrafish EEG predicts the efficacy of antiepileptic drugs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1055424
Abstract: Background: Pharmacological evaluation of antiepileptic drugs (AEDs) using mammalian animals takes long time and is expensive. The zebrafish is a species commonly used to study brain functions, neurological diseases, and drug toxicity, and attracts more… read more here.
Keywords: eeg; antiepileptic drugs; antiepileptic effects; eeg predicts ... See more keywords