Fingolimod Exerts only Temporary Antiepileptogenic Effects but Longer-Lasting Positive Effects on Behavior in the WAG/Rij Rat Absence Epilepsy Model
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DOI: 10.1007/s13311-017-0550-y
Abstract: One of the major challenges in the epilepsy field is identifying disease-modifying drugs in order to prevent or delay spontaneous recurrent seizure onset or to cure already established epilepsy. It has been recently reported that… read more here.
Keywords: wag rij; absence epilepsy; antiepileptogenic effects;
Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models
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DOI: 10.1111/epi.16055
Abstract: The cystine/glutamate antiporter system xc− could represent a new target for antiepileptogenic treatments due to its crucial roles in glutamate homeostasis and neuroinflammation. To demonstrate this, we compared epilepsy development and seizure susceptibility in xCT… read more here.
Keywords: epilepsy; system inactivation; system; effects system ... See more keywords
Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions
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DOI: 10.1111/epi.16975
Abstract: Infantile spasms may evolve into persistent epilepsies including Lennox‐Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple‐hit model) or focal cortical inflammation and determined the anti‐epileptogenic effects… read more here.
Keywords: infantile spasms; effects rapamycin; antiepileptogenic effects; due structural ... See more keywords
Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy
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DOI: 10.1111/epi.17561
Abstract: Epileptogenesis after status epilepticus (SE) has a faster onset in rats treated to reduce brain levels of the anticonvulsant neurosteroid allopregnanolone with the 5α‐reductase inhibitor finasteride; however, it still has to be evaluated whether treatments… read more here.
Keywords: trilostane kainic; model temporal; kainic acid; effects trilostane ... See more keywords