BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells
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DOI: 10.1007/s10549-017-4442-y
Abstract: PurposeWe previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound, the hydrochloride salt… read more here.
Keywords: nsc35446 hcl; antiestrogen resistant; breast cancer; ikkb promoter ... See more keywords
Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα+ Mammary Carcinomas.
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DOI: 10.1158/0008-5472.can-17-0985
Abstract: Although antiestrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα+) breast cancer, 25% to 40% fail to respond. Although multiple mechanisms underlie evasion of these treatments, including tumor heterogeneity and drug-resistant cancer… read more here.
Keywords: csc activity; antiestrogen; prolactin induced; cancer ... See more keywords
Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen-induced BimEL dependent apoptosis in ER+ breast cancer cells
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DOI: 10.3892/ijo.2022.5468
Abstract: The epidermal growth factor receptor (EGFR) is commonly upregulated in multiple cancer types, including breast cancer. In the present study, evidence is provided in support of the premise that upregulation of the EGFR/MEK1/MAPK1/2 signaling axis… read more here.
Keywords: cancer cells; antiestrogen; breast cancer; mek1 mapk1 ... See more keywords