Abstract 1657: Discovery of a first-in-class multifunctional TYMS non-classical antifolate inhibitors with potent in vivo activity that prolongs survival
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DOI: 10.1158/1538-7445.am2023-1657
Abstract: Thymidylate synthase (TYMS/TS) is overexpressed in many cancer types and is commonly associated with advanced disease. TYMS catalyzes the de novo synthesis reaction of deoxythymidine monophosphate (dTMP), one of the building blocks of DNA. Although… read more here.
Keywords: antifolate inhibitors; tyms; non classical; cancer ... See more keywords