Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients
Sign Up to like & getrecommendations! Published in 2017 at "Infection"
DOI: 10.1007/s15010-017-1042-z
Abstract: IntroductionBecause of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for therapeutic efficacy and safety.Materials and methodsThis review summarises published pharmacokinetic data on systemically administered antifungals focusing… read more here.
Keywords: drug interactions; treatment; pharmacokinetics antifungal; antifungal drugs ... See more keywords
Insights on the anticandidal activity of non-antifungal drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2019.07.004
Abstract: The search for new antifungal strategies to overcome Candida infections is essential and a matter of public health, due to the high mortality associated to candidiasis, the increasing incidence of resistance to antifungals and the… read more here.
Keywords: new antifungal; non antifungal; antifungal drugs; drug ... See more keywords
Antifungal Drugs in Newborns and Children.
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric clinics of North America"
DOI: 10.1016/j.pcl.2017.08.013
Abstract: Invasive fungal infections are a significant cause of morbidity and mortality in infants and children. Early diagnosis is critical, and treatment with the appropriate drug and dose should be initiated promptly. Although an increasing number… read more here.
Keywords: drugs newborns; newborns children; antifungal drugs;
Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00339
Abstract: Azoles are the most commonly used class of antifungal drugs, yet where they localize within fungal cells and how they are imported remain poorly understood. Azole antifungals target lanosterol 14α-demethylase, a cytochrome P450, encoded by… read more here.
Keywords: cytochrome p450; antifungal drugs; azole class; class antifungal ... See more keywords
Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00157
Abstract: New classes of antifungal drugs are an urgent unmet clinical need. One approach to the challenge of developing new antifungal drugs is to optimize the antifungal properties of currently used drugs with favorable pharmacologic properties,… read more here.
Keywords: mechanism; antifungal drugs; phenothiazines optimization; activity ... See more keywords
Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2018.1479726
Abstract: Abstract Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery,… read more here.
Keywords: administration; innovative nanocompounds; antifungal drugs; review ... See more keywords
An update on the safety and interactions of antifungal drugs in stem cell transplant recipients
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2017.1273900
Abstract: ABSTRACT Introduction: Invasive fungal diseases (IFDs) are a major cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT). Improvement in the management of IFDs have been achieved with the availability… read more here.
Keywords: safety; hsct; drug; stem cell ... See more keywords
Novel avenues for identification of new antifungal drugs and current challenges
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2097659
Abstract: ABSTRACT Introduction Some of the fungi have become pathogenic to humans, and these opportunistic pathogens are able to cause severe systemic mycoses. Areas covered The number of antifungals for systemic administration is limited and resistance… read more here.
Keywords: drugs current; identification new; antifungal drugs; new antifungal ... See more keywords
The unmet clinical need of novel antifungal drugs
Sign Up to like & getrecommendations! Published in 2017 at "Virulence"
DOI: 10.1080/21505594.2016.1276692
Abstract: The global impact of fungal infections on human health has recently been highlighted by several important publications, and advocacy groups. Although several factors undoubtedly contribute to the estimated 1.5 million deaths due to fungal disease… read more here.
Keywords: unmet clinical; novel antifungal; treatment; antifungal drugs ... See more keywords
A Review on Molecular Mechanisms of Antifungal Resistance in Candida glabrata: Update and Recent Advances.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial drug resistance"
DOI: 10.1089/mdr.2020.0235
Abstract: Candida glabrata is the second frequent etiologic agent of mucosal and invasive candidiasis. Based on the recent developments in molecular methods, C. glabrata has been introduced as a complex composed of C. glabrata, Candida nivariensis,… read more here.
Keywords: glabrata; antifungal resistance; antifungal drugs; resistance ... See more keywords
Conventional therapy and new antifungal drugs against Malassezia infections.
Sign Up to like & getrecommendations! Published in 2020 at "Medical mycology"
DOI: 10.1093/mmy/myaa087
Abstract: Malassezia yeasts are commensal microorganisms occurring on the skin of humans and animals causing dermatological disorders or systemic infections in severely immunocompromised hosts. Despite attempts to control such yeast infections with topical and systemic antifungals,… read more here.
Keywords: new antifungal; conventional therapy; antifungal drugs; therapy new ... See more keywords