Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26850-3
Abstract: Fungal pathogens pose a global threat to human health, with Candida albicans among the leading killers. Systematic analysis of essential genes provides a powerful strategy to discover potential antifungal targets. Here, we build a machine… read more here.
Keywords: machine learning; learning essentiality; leveraging machine; essentiality predictions ... See more keywords
Potential Antifungal Targets Based on Glucose Metabolism Pathways of Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00296
Abstract: In recent years, fungal infections have become a serious health problem. Candida albicans are considered as the fourth most common isolates associated with approximately 40% mortality in bloodstream infections among hospitalized patients. Due to various… read more here.
Keywords: metabolism pathways; metabolism; candida albicans; glucose metabolism ... See more keywords
Emerging Antifungal Targets and Strategies
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DOI: 10.3390/ijms23052756
Abstract: Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is an emerging need for the development of novel antifungals since those currently available are limited and… read more here.
Keywords: development; targets strategies; physiology; antifungal targets ... See more keywords
Sulfur Metabolism as a Promising Source of New Antifungal Targets
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8030295
Abstract: Fungal infections are a growing threat to human health. Despite their clinical relevance, there is a surprisingly limited availability of clinically approved antifungal agents, which is seriously aggravated by the recent appearance and fast spread… read more here.
Keywords: metabolism; sulfur metabolism; promising source; new antifungal ... See more keywords