Selective BET bromodomain inhibition as an antifungal therapeutic strategy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15482
Abstract: Invasive fungal infections cause significant morbidity and mortality among immunocompromised individuals, posing an urgent need for new antifungal therapeutic strategies. Here we investigate a chromatin-interacting module, the bromodomain (BD) from the BET family of proteins,… read more here.
Keywords: therapeutic strategy; antifungal therapeutic; inhibition; bet ... See more keywords
The Yin and Yang of Current Antifungal Therapeutic Strategies: How Can We Harness Our Natural Defenses?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00080
Abstract: Fungal infections have aroused much interest over the last years because of their involvement in several human diseases. Immunocompromission due to transplant-related therapies and malignant cancer treatments are risk factors for invasive fungal infections, but… read more here.
Keywords: current antifungal; antifungal therapeutic; yin yang; therapeutic strategies ... See more keywords