Confounders for interpreting the benefit of a biomarker-based strategy in early discontinuation of empirical antifungal therapy
Sign Up to like & getrecommendations! Published in 2018 at "Intensive Care Medicine"
DOI: 10.1007/s00134-018-5068-1
Abstract: Initial correspondence from Drs. Yamaga, Ohshimo and Shime We would like to discuss factors that potentially affect the results of a biomarker-based antifungal therapeutic algorithm in a recent issue of Intensive Care Medicine [1]. First,… read more here.
Keywords: medicine; antifungal therapy; confounders interpreting; biomarker based ... See more keywords
Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.115949
Abstract: Photodynamic antifungal therapy is a promising treatment for increasing drug-resistant fungi. However, low physiological solubility and low fungi-affinity of most potential photosensitizers limits their therapeutic efficacy. To improve the water-solubility and photodynamic antifungal activity of… read more here.
Keywords: antifungal therapy; zinc phthalocyanine; photodynamic antifungal;
Complications of hematopoietic stem transplantation: Fungal infections.
Sign Up to like & getrecommendations! Published in 2017 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2017.05.013
Abstract: Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk of invasive fungal infections, especially during the early neutropenic phase and severe graft-versus-host disease. Mold-active prophylaxis should be limited to the highest risk… read more here.
Keywords: antifungal therapy; risk; hsct; fungal infections ... See more keywords
Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111168
Abstract: The syndromes of mineralocorticoid excess describe a heterogeneous group of clinical manifestations leading to endocrine hypertension, typically either through direct activation of mineralocorticoid receptors or indirectly by impaired pre-receptor enzymatic regulation or through disturbed renal… read more here.
Keywords: antifungal therapy; mineralocorticoid excess; azoles syndrome; therapy azoles ... See more keywords
Application of Fluconazole-Loaded pH-Sensitive Lipid Nanoparticles for Enhanced Antifungal Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c05165
Abstract: Cryptococcus neoformans is a yeast-like fungus that can cause the life-threatening disease cryptococcal meningitis. Numerous reports have shown increased resistance of this fungus against antifungal treatments, such as fluconazole (Fluc), contributing to an 80% global… read more here.
Keywords: lipid nanoparticles; antifungal therapy; microscopy; sensitive lipid ... See more keywords
Design of amphotericin B oral formulation for antifungal therapy
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DOI: 10.1080/10717544.2016.1225852
Abstract: Abstract Amphotericin B (AmB) remains the “gold standard” for systemic antifungal therapy, even though new drugs are emerging as the attractive antifungal agents. Since AmB has negligible oral absorption as a consequence of its unfavorable… read more here.
Keywords: design amphotericin; antifungal therapy; amphotericin oral; oral formulation ... See more keywords
ALSUntangled No. 50: Antifungal Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2019.1622197
Abstract: Fungi are a group of living organisms that includes yeasts, molds, and mushrooms. Like bacteria, fungi normally live on the skin and inside the gastrointestinal tract of humans, but certain forms and overgrowths can cause… read more here.
Keywords: alsuntangled antifungal; antifungal therapy; oncology; hematology ... See more keywords
Role of Empiric Antifungal Therapy in Patients with Perforated Peptic Ulcers.
Sign Up to like & getrecommendations! Published in 2022 at "Surgical infections"
DOI: 10.1089/sur.2021.286
Abstract: Background: It is unclear if the addition of antifungal therapy for perforated peptic ulcers (PPU) leads to improved outcomes. We hypothesized that empiric antifungal therapy is associated with better clinical outcomes in critically ill patients… read more here.
Keywords: patients perforated; perforated peptic; antifungal therapy; peptic ulcers ... See more keywords
Outpatient parenteral antifungal therapy (OPAT) for invasive fungal infections with intermittent dosing of liposomal amphotericin B
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DOI: 10.1093/mmy/myz134
Abstract: Abstract Triazole resistant A. fumigatus has been documented in many parts of the world. In the Netherlands, incidence is now above 10% and results in the need for long-term parenteral therapy with liposomal amphotericin B… read more here.
Keywords: therapy opat; antifungal therapy; treatment; liposomal amphotericin ... See more keywords
Short Course of Antifungal Therapy in Patients With Uncomplicated Candida Bloodstream Infection: Another Case of Less Is More in the Clinical Setting?
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac656
Abstract: Abstract Background The objective of this study was to compare the clinical outcomes of patients receiving a short course (SC) vs a prolonged course (PC) of antifungal therapy for uncomplicated Candida bloodstream infections (BSIs). Methods… read more here.
Keywords: bsi; uncomplicated candida; antifungal therapy; course ... See more keywords
Untargeted antifungal therapy in adult patients with complicated intra‐abdominal infection: a systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.13031
Abstract: Systematic reviews comparing untargeted antifungal treatment with placebo or no treatment in critically ill patients have provided conflicting results. We aimed to assess patient‐important benefits and harms of untargeted antifungal therapy vs. placebo or no… read more here.
Keywords: antifungal therapy; patients complicated; untargeted antifungal; adult patients ... See more keywords