Engineered Curli Nanofilaments as a Self-Adjuvanted Antigen Delivery Platform.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300224
Abstract: Proteinaceous nanoparticles constitute efficient antigen delivery systems in vaccine formulations due to their size and repetitive nature that mimic most invading pathogens and promote immune activation. Nonetheless, the co-administration of an adjuvant with subunit nanovaccines… read more here.
Keywords: self adjuvanted; delivery platform; antigen; antigen delivery ... See more keywords
A novel antigen delivery system induces strong humoral and CTL immune responses.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.04.035
Abstract: New strategies with the ability to enhance both the humoral and cellular immune responses remain a priority for the development of future therapeutic cancer vaccines. In this study, we took advantage of β-glucan particles (GPs)… read more here.
Keywords: immune; system; antigen delivery; humoral cellular ... See more keywords
Nice and slow make the germinal centers go: measured and escalating antigen delivery enhance durability and quality of humoral immune responses against HIV‐1
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12596
Abstract: A recently published article has confirmed that a novel immunization method of sustained and escalating antigen delivery augments the magnitude, quality and durability of humoral immune responses. read more here.
Keywords: immune responses; humoral immune; antigen delivery; escalating antigen ... See more keywords
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.158089
Abstract: Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). How foreign lipid antigens are delivered… read more here.
Keywords: activation; lipid antigens; antigen delivery; antigen ... See more keywords
Tumor treatment by pHLIP-targeted antigen delivery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1082290
Abstract: Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to tumors by pH… read more here.
Keywords: targeted antigen; phlip; low insertion; antigen delivery ... See more keywords
Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.732298
Abstract: Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation of the immune system, professional antigen presenting cells have proven to be key… read more here.
Keywords: antigen delivery; antigen; langerhans cells; protein antigen ... See more keywords
Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Antibodies"
DOI: 10.3390/antib11010008
Abstract: Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools… read more here.
Keywords: applications antibody; antigen delivery; dendritic cells; cells vivo ... See more keywords
Mannose Receptor-Mediated Carbon Nanotubes as an Antigen Delivery System to Enhance Immune Response Both In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084239
Abstract: Carbon nanotubes (CNTs) are carbon allotropes consisting of one, two, or more concentric rolled graphene layers. These can intrinsically regulate immunity by activating the innate immune system. Mannose receptors (MR), a subgroup of the C-type… read more here.
Keywords: system; delivery system; antigen delivery; carbon nanotubes ... See more keywords
Development of pH-sensitive Dextran Derivatives with Strong Adjuvant Function and Their Application to Antigen Delivery
Sign Up to like & getrecommendations! Published in 2017 at "Membranes"
DOI: 10.3390/membranes7030041
Abstract: To achieve efficient cancer immunotherapy, the induction of cytotoxic T lymphocyte-based cellular immunity is necessary. In order to induce cellular immunity, antigen carriers that can deliver antigen into cytosol of antigen presenting cells and can… read more here.
Keywords: dex; antigen delivery; mglu dex; dextran ... See more keywords
Angled Insertion of Microneedles for Targeted Antigen Delivery to the Epidermis
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020347
Abstract: Peanut and tree nut allergies account for most food-induced anaphylactic events. The standard allergy immunotherapy approach involves subcutaneous injection, which is challenging because severe adverse reactions can occur when antigens spread systemically. Allergen localization within… read more here.
Keywords: delivery; delivery epidermis; insertion; angled insertion ... See more keywords
Synthesis and Characterization of Innovative Microgels Based on Polyacrylic Acid and Microalgae Cell Wall and Their Potential as Antigen Delivery Vehicles
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010133
Abstract: In this study, hybrid polyacrylic acid and Schizochytrium sp. microalgae (PAA/Schizo) microgels were synthesized by inverse emulsion assisted by ultrasound using the cell wall fraction as crosslinker. Physicochemical characterization of PAA/Schizo microgels revealed polymeric spherical… read more here.
Keywords: schizo microgels; cell wall; antigen delivery; paa schizo ... See more keywords